Tbio MRGPRD Mas-related G-protein coupled receptor member D

Protein Summary

Description

May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for beta-alanine. Beta-alanine at micromolar doses specifically evoked Ca(2+) influx in cells expressing the receptor. Beta-alanine decreases forskolin-stimulated cAMP production in cells expressing the receptor, suggesting that the receptor couples with G-protein G(q) and G(i).

Uniprot Accession IDs

• Q8TDS7
• Q8NGK7

Gene Name

• MRGPRD

Ensembl ID

• ENST00000309106
• ENSP00000310631
• ENSG00000172938

Symbol

• MRGD
• MRGD
• TGR7

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.67
cell line	0.64
protein domain	0.58
metabolite	0.45
tissue sample	0.4

Protein Classes

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Mas Proto-oncogene And Mas-related (Mrgs) Receptor / Mas-related G-protein Coupled Receptor Member D

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.01   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 97   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.01   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 97   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0