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Tbio
MRC2
C-type mannose receptor 2

Protein Summary
Description
May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs). This gene encodes a member of the mannose receptor family of proteins that contain a fibronectin type II domain and multiple C-type lectin-like domains. The encoded protein plays a role in extracellular matrix remodeling by mediating the internalization and lysosomal degrad ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000303375
  • ENSP00000307513
  • ENSG00000011028

Symbol
  • CLEC13E
  • ENDO180
  • KIAA0709
  • UPARAP
  • CD280
  • UPARAP
  • CLEC13E
  • ENDO180
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
protein domain
0.92
PubMedID
0.86
transcription factor perturbation
0.84
transcription factor
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.73   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 235   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.73   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 235   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (33)
FAM19A4
Tbio
Novelty:  0.04305684
p_int:  0.999901678
p_ni:  0.000098322
Score:  0.236
Data Source:  BioPlex,STRINGDB
LGALS8
Tchem
Novelty:  0.00623836
p_int:  0.999634828
p_ni:  0.000365172
Score:  0.252
Data Source:  BioPlex,STRINGDB
LGALS3
Tchem
Novelty:  0.00032754
p_int:  0.998766244
p_ni:  0.001233754
p_wrong:  1e-9
Score:  0.408
Data Source:  BioPlex,STRINGDB
FAM19A2
Tbio
Novelty:  0.28999346
p_int:  0.998495485
p_ni:  0.001504515
Data Source:  BioPlex
LGALS9
Tchem
Novelty:  0.00381766
p_int:  0.998363022
p_ni:  0.001636978
Score:  0.297
Data Source:  BioPlex,STRINGDB
NDP
Tbio
Novelty:  0.01020963
p_int:  0.97272045
p_ni:  0.027278993
p_wrong:  5.57e-7
Data Source:  BioPlex
ST8SIA4
Tbio
Family:  Enzyme
Novelty:  0.00338436
p_int:  0.942253317
p_ni:  0.057746682
Data Source:  BioPlex
PATE1
Tbio
Novelty:  0.0705075
p_int:  0.919645483
p_ni:  0.080349314
p_wrong:  0.000005203
Data Source:  BioPlex
C1QTNF9B
Tdark
Novelty:  0.7643008
p_int:  0.914995336
p_ni:  0.084994804
p_wrong:  0.00000986
Data Source:  BioPlex
FAM19A3
Tdark
Novelty:  0.37183557
p_int:  0.895956798
p_ni:  0.104043202
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing-Cross presentation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Cross-presentation of soluble exogenous antigens (endosomes)
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing-Cross presentation
Class I MHC mediated antigen processing & presentation
Cross-presentation of soluble exogenous antigens (endosomes)
Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
1
1
74.1
pulse pressure measurement
1
1
1
65
appendicular lean mass
1
1
1
56.3
migraine disorder
1
1
0
1
51.4
systolic blood pressure
1
1
1
49.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
74.1
pulse pressure measurement
1
65
appendicular lean mass
1
56.3
migraine disorder
0
1
51.4
systolic blood pressure
1
49.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mannose receptor C type 2
VGNC:9462
454788
Macaque
mannose receptor C type 2
717576
Mouse
MGI:107818
17534
Rat
RGD:1559436
498011
Dog
mannose receptor C type 2
VGNC:43360
100688560
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mannose receptor C type 2
Macaque
mannose receptor C type 2
Mouse
Rat
Dog
mannose receptor C type 2
Publication Statistics
PubMed Score 131.73
PubMed score by year
PubTator Score 64.87
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title