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Tbio
MPZL1
Myelin protein zero-like protein 1

Protein Summary
Description
Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359523
  • ENSP00000352513
  • ENSG00000197965
  • ENST00000392121
  • ENSP00000375968
  • ENST00000474859
  • ENSP00000420455

Symbol
  • PZR
  • PZR
  • PZRa
  • PZRb
  • PZR1b
  • MPZL1b
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
transcription factor perturbation
0.97
disease perturbation
0.9
transcription factor binding site profile
0.85
virus perturbation
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.83   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 107   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.83   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (65)
IFIH1
Tbio
Family:  Enzyme
Novelty:  0.00111499
p_int:  0.999995159
p_ni:  0.000004813
p_wrong:  2.8e-8
Score:  0.351
Data Source:  BioPlex,STRINGDB
SIGLECL1
Tdark
p_int:  0.999731078
p_ni:  0.000268865
p_wrong:  5.8e-8
Data Source:  BioPlex
C6orf136
Tdark
Novelty:  2.06079552
p_int:  0.999031658
p_ni:  0.000868922
p_wrong:  0.000099421
Data Source:  BioPlex
PTPN11
Tchem
Family:  Enzyme
Novelty:  0.00073124
p_int:  0.998466301
p_ni:  0.001533699
Score:  0.809
Data Source:  BioPlex,STRINGDB
TMEM30B
Tbio
Novelty:  0.26735006
p_int:  0.994763823
p_ni:  0.005216536
p_wrong:  0.000019641
Data Source:  BioPlex
LIPF
Tclin
Family:  Enzyme
Novelty:  0.03073254
p_int:  0.994620857
p_ni:  0.005312886
p_wrong:  0.000066257
Score:  0.198
Data Source:  BioPlex,STRINGDB
CTLA4
Tclin
Novelty:  0.00012781
p_int:  0.993624711
p_ni:  0.006375252
p_wrong:  3.7e-8
Data Source:  BioPlex
NOXRED1
Tdark
Family:  Enzyme
Novelty:  1.78947368
p_int:  0.987035647
p_ni:  0.01296428
p_wrong:  7.3e-8
Score:  0.507
Data Source:  BioPlex,STRINGDB
LGALS3
Tchem
Novelty:  0.00032754
p_int:  0.986525805
p_ni:  0.013474175
p_wrong:  2e-8
Data Source:  BioPlex
PLAC9
Tdark
Novelty:  0.23764669
p_int:  0.981330121
p_ni:  0.018669593
p_wrong:  2.86e-7
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
leukocyte count
1
1
1
70.5
myeloid white cell count
1
1
1
69.2
neutrophil count
2
1
2
67.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
leukocyte count
1
70.5
myeloid white cell count
1
69.2
neutrophil count
2
67.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
myelin protein zero like 1
698437
Mouse
MGI:1915731
68481
Rat
RGD:1359140
360871
Dog
myelin protein zero like 1
VGNC:43354
480088
Horse
myelin protein zero like 1
VGNC:20301
100056894
Species
Name
OMA
EggNOG
Inparanoid
Macaque
myelin protein zero like 1
Mouse
Rat
Dog
myelin protein zero like 1
Horse
myelin protein zero like 1
Publication Statistics
PubMed Score 36.83
PubMed score by year
PubTator Score 9.89
PubTator score by year
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Related Publications
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PMID
Year
Title