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Tbio
MPZ
Myelin protein P0

Protein Summary
Description
Is an adhesion molecule necessary for normal myelination in the peripheral nervous system. It mediates adhesion between adjacent myelin wraps and ultimately drives myelin compaction. This gene is specifically expressed in Schwann cells of the peripheral nervous system and encodes a type I transmembrane glycoprotein that is a major structural protein of the peripheral myelin sheath. The encoded protein contains a large hydrophobic extracellular domain and a smaller basic intracellular domain, which are essential for the formation and stabilization of the multilamellar structure of the compact myelin. Mutations in this gene are associated with autosomal dominant form of Charcot-Marie-Tooth disease type 1 (CMT1B) and other polyneuropathies, such as Dejerine-Sottas syndrome (DSS) and congenital hypomyelinating neuropathy (CHN). A recent study showed that two isoforms are produced from the same mRNA by use of alternative in-frame translation termination codons via a stop codon readthrough m ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000463290
  • ENSP00000431538
  • ENSG00000158887
  • ENST00000533357
  • ENSP00000432943

Symbol
  • P0
  • CHM
  • DSS
  • MPP
  • CHN2
  • CMT1
  • CMT1B
  • CMT2I
  • CMT2J
  • CMT4E
  • CMTDI3
  • CMTDID
  • HMSNIB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
gene perturbation
0.74
phenotype
0.69
cell type or tissue
0.62
biological term
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 465.03   (req: < 5)
Gene RIFs: 80   (req: <= 3)
Antibodies: 365   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 465.03   (req: >= 5)
Gene RIFs: 80   (req: > 3)
Antibodies: 365   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (65)
PMP22
Tbio
Novelty:  0.00256307
Score:  0.919
Data Source:  STRINGDB
GJB1
Tbio
Novelty:  0.00109019
Score:  0.86
Data Source:  STRINGDB
MPZL1
Tbio
Novelty:  0.03292508
Score:  0.817
Data Source:  STRINGDB
SOX10
Tbio
Family:  TF
Novelty:  0.00130552
Score:  0.807
Data Source:  STRINGDB
EGR2
Tbio
Family:  TF
Novelty:  0.00215433
Score:  0.793
Data Source:  STRINGDB
GDAP1
Tbio
Novelty:  0.00682376
Score:  0.767
Data Source:  STRINGDB
PRX
Tbio
Novelty:  0.01867283
Score:  0.758
Data Source:  STRINGDB
MBP
Tbio
Novelty:  0.00016333
Score:  0.753
Data Source:  STRINGDB
PLP1
Tbio
Novelty:  0.00129083
Score:  0.727
Data Source:  STRINGDB
SH3TC2
Tbio
Novelty:  0.0205934
Score:  0.721
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
2
4
93
blood protein measurement
1
3
3
90.9
blood metabolite measurement
2
2
2
83
4
2
0
1.1
82.8
serum non-albumin protein measurement
1
2
2
82
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
4
93
blood protein measurement
3
90.9
blood metabolite measurement
2
83
0
1.1
82.8
serum non-albumin protein measurement
2
82
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
myelin protein zero
VGNC:1328
747431
Macaque
myelin protein zero
719969
Mouse
MGI:103177
17528
Rat
RGD:3109
24564
Dog
myelin protein zero
VGNC:43353
488654
Species
Name
OMA
EggNOG
Inparanoid
Chimp
myelin protein zero
Macaque
myelin protein zero
Mouse
Rat
Dog
myelin protein zero
Publication Statistics
PubMed Score 465.03
PubMed score by year
PubTator Score 432.48
PubTator score by year
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Related Publications
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PMID
Year
Title