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Tbio
MPRIP
Myosin phosphatase Rho-interacting protein

Protein Summary
Description
Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341712
  • ENSP00000342379
  • ENSG00000133030
  • ENST00000395811
  • ENSP00000379156

Symbol
  • KIAA0864
  • MRIP
  • RHOIP3
  • MRIP
  • RIP3
  • M-RIP
  • RHOIP3
  • p116Rip
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
disease perturbation
0.96
ligand (protein) perturbation
0.83
virus perturbation
0.79
microRNA
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.82   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 191   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.82   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 191   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0