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Tdark
MPPED1
Metallophosphoesterase domain-containing protein 1

Protein Summary
Description
May have metallophosphoesterase activity (in vitro).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000417669
  • ENSP00000388137
  • ENSG00000186732
  • ENST00000443721
  • ENSP00000400686

Symbol
  • C22orf1
  • FAM1A
  • 239AB
  • FAM1A
  • C22orf1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.61
PubMedID
0.57
cell type or tissue
0.53
cell line
0.52
gene perturbation
0.48


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.97   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 118   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.97   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 118   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (64)
PHKB
Tbio
Family:  Enzyme
Novelty:  0.05506418
p_int:  0.999999988
p_ni:  1.1e-8
p_wrong:  1e-9
Score:  0.554
Data Source:  BioPlex,STRINGDB
PHKA2
Tbio
Family:  Kinase
Novelty:  0.00461145
p_int:  0.999999963
p_ni:  3.7e-8
Score:  0.702
Data Source:  BioPlex,STRINGDB
PHKG2
Tchem
Family:  Kinase
Novelty:  0.064884
p_int:  0.999998861
p_ni:  0.000001139
Score:  0.554
Data Source:  BioPlex,STRINGDB
PHKA1
Tbio
Family:  Kinase
Novelty:  0.02895127
p_int:  0.999997077
p_ni:  0.000002923
p_wrong:  1e-9
Score:  0.773
Data Source:  BioPlex,STRINGDB
NR2F6
Tbio
Family:  NR
Novelty:  0.02314124
p_int:  0.99999526
p_ni:  0.00000474
Score:  0.729
Data Source:  BioPlex,STRINGDB
NARF
Tbio
Novelty:  0.06990726
p_int:  0.999993718
p_ni:  0.000006263
p_wrong:  1.9e-8
Score:  0.303
Data Source:  BioPlex,STRINGDB
UPRT
Tbio
Family:  Enzyme
Novelty:  0.00506163
p_int:  0.999959193
p_ni:  0.00000531
p_wrong:  0.000035497
Score:  0.686
Data Source:  BioPlex,STRINGDB
CLUH
Tbio
Novelty:  0.14027296
p_int:  0.999820633
p_ni:  0.000179367
Data Source:  BioPlex
UCK1
Tbio
Family:  Kinase
Novelty:  0.10536869
p_int:  0.999792265
p_ni:  0.000145404
p_wrong:  0.000062331
Score:  0.735
Data Source:  BioPlex,STRINGDB
UCKL1
Tbio
Family:  Kinase
Novelty:  0.18522799
p_int:  0.999598486
p_ni:  0.000401514
Score:  0.631
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
3
4
72.6
sleep measurement
1
1
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
72.6
sleep measurement
1
24.5
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:106316
223726
Rat
RGD:1308244
362971
Dog
metallophosphoesterase domain containing 1
VGNC:43349
609458
Horse
metallophosphoesterase domain containing 1
VGNC:20296
100050170
Chicken
metallophosphoesterase domain containing 1
CGNC:50709
418229
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
metallophosphoesterase domain containing 1
Horse
metallophosphoesterase domain containing 1
Chicken
metallophosphoesterase domain containing 1
Publication Statistics
PubMed Score 1.97
PubMed score by year
PubTator Score 1.07
PubTator score by year
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Related Publications
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PMID
Year
Title