Tbio MPPE1 Metallophosphoesterase 1

Protein Summary

Description

Metallophosphoesterase required for transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI-anchor proteins.

Uniprot Accession IDs

• Q53F39
• B0YJ39
• B0YJ40
• B0YJ41
• B5ME53
• B7WNJ3
• D3DUI5
• D3DUI7
• Q6GMP1
• Q8TAD6
• Q8TE26
• Q8WZ32
• Q9BU58
• Q9H958
• Q9HAI4

Gene Name

• MPPE1

Ensembl ID

• ENST00000309976
• ENSP00000311200
• ENSG00000154889
• ENST00000317235
• ENSP00000327257
• ENST00000496196
• ENSP00000433950
• ENST00000588072
• ENSP00000465894

Symbol

• PGAP5
• PGAP5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.83
virus perturbation	0.76
cell type or tissue	0.73
molecular function	0.7
cellular component	0.69

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.39   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 128   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.39   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 128   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (112)

Explore Interacting Targets

1 – 10 of 112

• See Interactions on String-DB

EDEM1

Tbio

Family:  Enzyme

Novelty:  0.01157706

p_int:  0.999979342

p_ni:  0.000020658

Data Source:  BioPlex

ICAM4

Tbio

Novelty:  0.0269875

p_int:  0.999961634

p_ni:  0.000038238

p_wrong:  1.29e-7

Score:  0.187

Data Source:  BioPlex,STRINGDB

TMEM186

Tdark

Novelty:  0.59951294

p_int:  0.999885931

p_ni:  0.000114069

Data Source:  BioPlex

UGT3A2

Tbio

Family:  Enzyme

Novelty:  0.35904542

p_int:  0.999869627

p_ni:  0.000091131

p_wrong:  0.000039242

Data Source:  BioPlex

GINM1

Tdark

Novelty:  1.0701107

p_int:  0.999712957

p_ni:  0.000222004

p_wrong:  0.000065039

Data Source:  BioPlex

PIGB

Tbio

Family:  Enzyme

Novelty:  0.05237713

p_int:  0.999689441

p_ni:  0.000096685

p_wrong:  0.000213874

Score:  0.437

Data Source:  BioPlex,STRINGDB

SEMA6A

Tbio

Novelty:  0.00624456

p_int:  0.999673991

p_ni:  0.000325991

p_wrong:  1.8e-8

Score:  0.292

Data Source:  BioPlex,STRINGDB

TMEM59L

Tbio

Novelty:  0.22745646

p_int:  0.999421563

p_ni:  0.000577702

p_wrong:  7.35e-7

Data Source:  BioPlex

GALNT4

Tbio

Family:  Enzyme

Novelty:  0.05200323

p_int:  0.999400664

p_ni:  0.00016486

p_wrong:  0.000434476

Score:  0.171

Data Source:  BioPlex,STRINGDB

DHFR2

Tbio

Family:  Enzyme

Novelty:  0.02374466

p_int:  0.999375393

p_ni:  0.000603158

p_wrong:  0.000021449

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (13)

Functions (3)

Components (8)

Processes (2)

Find Similar Targets

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
GPI anchor binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
manganese ion binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
phosphoric diester hydrolase activity	Inferred from Sequence or structural Similarity (ISS)	UniProtKB

Disease Associations ()

No disease associations found

GWAS Traits (2)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
hemoglobin measurement	EFO_0004509	2	2	3		63
hematocrit	EFO_0004348	2	2	2		62.6

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
hemoglobin measurement	EFO_0004509	3		63
hematocrit	EFO_0004348	2		62.6

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
ER-Golgi transport
Golgi apparatus
GPI-anchor biosynthesis
Hydrolase
Manganese
Membrane
Metal-binding
Polymorphism

GWAS Trait Find Similar Targets

No Header	No Header
hematocrit
hemoglobin measurement

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	metallophosphoesterase 1	VGNC:5187	468471
Mouse	metallophosphoesterase 1	MGI:2661311	225651
Rat	metallophosphoesterase 1	RGD:1309184	361344
Dog	metallophosphoesterase 1	VGNC:43348	490556
Horse	metallophosphoesterase 1	VGNC:20295	100058827

Species	Name	OMA	EggNOG	Inparanoid
Chimp	metallophosphoesterase 1
Mouse	metallophosphoesterase 1
Rat	metallophosphoesterase 1
Dog	metallophosphoesterase 1
Horse	metallophosphoesterase 1

Publication Statistics

PubMed Score 6.39

PubMed score by year

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PubTator Score 5.92

PubTator score by year

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Related Publications

Text Mined References (11)

GeneRif Annotations (4)

Items per page:

10

0 of 0

PMID	Year	Title