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Tbio
MPPE1
Metallophosphoesterase 1

Protein Summary
Description
Metallophosphoesterase required for transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI-anchor proteins.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309976
  • ENSP00000311200
  • ENSG00000154889
  • ENST00000317235
  • ENSP00000327257
  • ENST00000496196
  • ENSP00000433950
  • ENST00000588072
  • ENSP00000465894

Symbol
  • PGAP5
  • PGAP5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.83
virus perturbation
0.76
cell type or tissue
0.73
molecular function
0.7
cellular component
0.69


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.72   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 128   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.72   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 128   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (112)
EDEM1
Tbio
Family:  Enzyme
Novelty:  0.01157706
p_int:  0.999979342
p_ni:  0.000020658
Data Source:  BioPlex
ICAM4
Tbio
Novelty:  0.0269875
p_int:  0.999961634
p_ni:  0.000038238
p_wrong:  1.29e-7
Score:  0.187
Data Source:  BioPlex,STRINGDB
TMEM186
Tdark
Novelty:  0.59951294
p_int:  0.999885931
p_ni:  0.000114069
Data Source:  BioPlex
UGT3A2
Tbio
Family:  Enzyme
Novelty:  0.35904542
p_int:  0.999869627
p_ni:  0.000091131
p_wrong:  0.000039242
Data Source:  BioPlex
GINM1
Tdark
Novelty:  1.0701107
p_int:  0.999712957
p_ni:  0.000222004
p_wrong:  0.000065039
Data Source:  BioPlex
PIGB
Tbio
Family:  Enzyme
Novelty:  0.05237713
p_int:  0.999689441
p_ni:  0.000096685
p_wrong:  0.000213874
Score:  0.437
Data Source:  BioPlex,STRINGDB
SEMA6A
Tbio
Novelty:  0.00624456
p_int:  0.999673991
p_ni:  0.000325991
p_wrong:  1.8e-8
Score:  0.292
Data Source:  BioPlex,STRINGDB
TMEM59L
Tbio
Novelty:  0.22745646
p_int:  0.999421563
p_ni:  0.000577702
p_wrong:  7.35e-7
Data Source:  BioPlex
GALNT4
Tbio
Family:  Enzyme
Novelty:  0.05200323
p_int:  0.999400664
p_ni:  0.00016486
p_wrong:  0.000434476
Score:  0.171
Data Source:  BioPlex,STRINGDB
DHFR2
Tbio
Family:  Enzyme
Novelty:  0.02374466
p_int:  0.999375393
p_ni:  0.000603158
p_wrong:  0.000021449
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
2
2
3
53
hematocrit
2
2
2
52.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
3
53
hematocrit
2
52.6
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
metallophosphoesterase 1
VGNC:5187
468471
Mouse
MGI:2661311
225651
Rat
RGD:1309184
361344
Dog
metallophosphoesterase 1
VGNC:43348
490556
Horse
metallophosphoesterase 1
VGNC:20295
100058827
Species
Name
OMA
EggNOG
Inparanoid
Chimp
metallophosphoesterase 1
Mouse
Rat
Dog
metallophosphoesterase 1
Horse
metallophosphoesterase 1
Publication Statistics
PubMed Score 8.72
PubMed score by year
PubTator Score 5.92
PubTator score by year
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Related Publications
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PMID
Year
Title