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Tbio
MPP2
MAGUK p55 subfamily member 2

Protein Summary
Description
Postsynaptic MAGUK scaffold protein that links CADM1 cell adhesion molecules to core components of the postsynaptic density (By similarity). In CA1 pyramidal neurons, required for synaptic KCNN2-containing channel function and long-term potentiation expression (By similarity). Seems to negatively regulate SRC function in epithelial cells (PubMed:19665017). Palmitoylated membrane protein 2 is a member of a family of membrane-associated proteins termed MAGUKs (membrane-associated guanylate kinase homologs). MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intracellular junctions. Palmitoylated membrane protein 2 contains a conserved sequence, called the SH3 (src homology 3) motif, found in several other proteins that associate with the cytoskeleton and are suspected to play important roles in signal transduction. [provided by RefSeq, Jul 2008]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
protein domain
0.99
interacting protein
0.95
microRNA
0.78
tissue sample
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.32   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 208   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.32   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 208   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (78)
LIN7C
Tbio
Novelty:  0.06778878
p_int:  1
Score:  0.956
Data Source:  BioPlex,STRINGDB
DLG1
Tbio
Novelty:  0.0050926
p_int:  0.999999973
p_ni:  2.7e-8
Score:  0.787
Data Source:  BioPlex,STRINGDB
LIN7B
Tbio
Novelty:  0.12689192
p_int:  0.999999961
p_ni:  1.3e-8
p_wrong:  2.7e-8
Score:  0.978
Data Source:  BioPlex,STRINGDB
CDA
Tclin
Family:  Enzyme
Novelty:  0.00280981
p_int:  0.999999553
p_ni:  4.47e-7
Score:  0.714
Data Source:  BioPlex,STRINGDB
LIN7A
Tbio
Novelty:  0.0202389
p_int:  0.999976893
p_ni:  0.000023107
Score:  0.946
Data Source:  BioPlex,STRINGDB
MPP6
Tbio
Novelty:  0.08883057
p_int:  0.999962248
p_ni:  0.000037751
p_wrong:  1e-9
Score:  0.826
Data Source:  BioPlex,STRINGDB
SLC20A1
Tbio
Family:  Transporter
Novelty:  0.01123373
p_int:  0.999830263
p_ni:  0.000169737
Score:  0.719
Data Source:  BioPlex,STRINGDB
NGB
Tbio
Novelty:  0.00247805
p_int:  0.998551676
p_ni:  0.001448324
Score:  0.285
Data Source:  BioPlex,STRINGDB
THRSP
Tbio
Novelty:  0.00938864
p_int:  0.995693685
p_ni:  0.004306315
Data Source:  BioPlex
GID4
Tbio
Novelty:  0.05252674
p_int:  0.981881416
p_ni:  0.018118584
Score:  0.153
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
7
6
9
99
high density lipoprotein cholesterol measurement
6
4
9
98.2
apolipoprotein A 1 measurement
1
1
1
87.7
metabolic syndrome
1
1
1
83
bone density
1
2
2
68.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
9
99
high density lipoprotein cholesterol measurement
9
98.2
apolipoprotein A 1 measurement
1
87.7
metabolic syndrome
1
83
bone density
2
68.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
membrane palmitoylated protein 2
VGNC:12472
454717
Mouse
MGI:1858257
50997
Rat
RGD:620014
85275
Dog
membrane palmitoylated protein 2
VGNC:43343
490945
Cow
membrane palmitoylated protein 2
VGNC:31583
509346
Species
Name
OMA
EggNOG
Inparanoid
Chimp
membrane palmitoylated protein 2
Mouse
Rat
Dog
membrane palmitoylated protein 2
Cow
membrane palmitoylated protein 2
Publication Statistics
PubMed Score 24.32
PubMed score by year
PubTator Score 13.03
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title