Protein Summary
Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity. Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils. [provided by RefSeq, Nov 2014]
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4857.81 (req: < 5)
Gene RIFs: 415 (req: <= 3)
Antibodies: 1584 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4857.81 (req: >= 5)
Gene RIFs: 415 (req: > 3)
Antibodies: 1584 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 24
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 175
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 6
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (6)
Active Ligands (175)
Protein-Protein Interactions (376)
ICE2
Novelty: 0.03407933
p_int: 0.99999908
p_ni: 3.91e-7
p_wrong: 5.29e-7
Score: 0.311
Data Source: BioPlex,STRINGDB
FRMD1
Novelty: 0.96833141
p_int: 0.999997586
p_ni: 0.000001353
p_wrong: 0.000001061
Score: 0.256
Data Source: BioPlex,STRINGDB
APCDD1
Novelty: 0.25122542
p_int: 0.99999131
p_ni: 0.000008672
p_wrong: 1.7e-8
Score: 0.252
Data Source: BioPlex,STRINGDB
PLB1
Family: Enzyme
Novelty: 0.01628403
p_int: 0.999827172
p_ni: 0.00001532
p_wrong: 0.000157507
Score: 0.386
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (15)
Reactome (5)
KEGG (4)
PathwayCommons (2)
WikiPathways (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Events associated with phagocytolytic activity of PMN cells | ||||
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Reactome | Neutrophil degranulation | ||||
Reactome | ROS and RNS production in phagocytes | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Events associated with phagocytolytic activity of PMN cells | ||||
Immune System | ||||
Innate Immune System | ||||
Neutrophil degranulation | ||||
ROS and RNS production in phagocytes | ||||
Viral Interactions (0)
Gene Ontology Terms (34)
Functions (5)
Components (10)
Processes (19)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (27)
Items per page:
1 – 5 of 27
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
monocyte percentage of leukocytes | 2 | 7 | 8 | 98.6 | |||||
neutrophil count | 2 | 4 | 4 | 96.5 | |||||
myeloperoxidase measurement | 2 | 3 | 3 | 95.8 | |||||
neutrophil percentage of leukocytes | 2 | 4 | 5 | 93.4 | |||||
leukocyte count | 2 | 3 | 3 | 93.2 | |||||
Items per page:
1 – 5 of 27
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
monocyte percentage of leukocytes | 8 | 98.6 | |||||
neutrophil count | 4 | 96.5 | |||||
myeloperoxidase measurement | 3 | 95.8 | |||||
neutrophil percentage of leukocytes | 5 | 93.4 | |||||
leukocyte count | 3 | 93.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | myeloperoxidase | VGNC:9442 | 748680 | |||||
Macaque | myeloperoxidase | 714246 | ||||||
Mouse | MGI:97137 | 17523 | ||||||
Dog | myeloperoxidase | VGNC:43341 | 609986 | |||||
Horse | myeloperoxidase | VGNC:20288 | 100070920 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | myeloperoxidase | |||||
Macaque | myeloperoxidase | |||||
Mouse | ||||||
Dog | myeloperoxidase | |||||
Horse | myeloperoxidase | |||||
Publication Statistics
PubMed Score 4857.81
PubMed score by year
PubTator Score 5992.76
PubTator score by year
Related Publications
Text Mined References (571)
GeneRif Annotations (415)
Items per page:
0 of 0
PMID | Year | Title |
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