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Tchem
MPO
Myeloperoxidase

Protein Summary
Description
Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity. Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils. [provided by RefSeq, Nov 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000225275
  • ENSP00000225275
  • ENSG00000005381
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
chemical
1
disease
0.9
drug
0.88
cellular component
0.86


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4857.81   (req: < 5)
Gene RIFs: 415   (req: <= 3)
Antibodies: 1584   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4857.81   (req: >= 5)
Gene RIFs: 415   (req: > 3)
Antibodies: 1584   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 175
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (175)
tryptamine
Rendered image for tryptamine
5-fluorotryptamine
Rendered image for 5-fluorotryptamine
CHEMBL333928
Rendered image for CHEMBL333928
GMQ
Rendered image for GMQ
CHEMBL2347170
Rendered image for CHEMBL2347170
CHEMBL2347168
Rendered image for CHEMBL2347168
CHEMBL4482878
Rendered image for CHEMBL4482878
CHEMBL2347167
Rendered image for CHEMBL2347167
Protein-Protein Interactions (376)
ICE2
Tbio
Novelty:  0.03407933
p_int:  0.99999908
p_ni:  3.91e-7
p_wrong:  5.29e-7
Score:  0.311
Data Source:  BioPlex,STRINGDB
FRMD1
Tdark
Novelty:  0.96833141
p_int:  0.999997586
p_ni:  0.000001353
p_wrong:  0.000001061
Score:  0.256
Data Source:  BioPlex,STRINGDB
APCDD1
Tbio
Novelty:  0.25122542
p_int:  0.99999131
p_ni:  0.000008672
p_wrong:  1.7e-8
Score:  0.252
Data Source:  BioPlex,STRINGDB
PLB1
Tbio
Family:  Enzyme
Novelty:  0.01628403
p_int:  0.999827172
p_ni:  0.00001532
p_wrong:  0.000157507
Score:  0.386
Data Source:  BioPlex,STRINGDB
PRTN3
Tchem
Family:  Enzyme
Novelty:  0.00022728
Score:  0.996
Data Source:  STRINGDB
ELANE
Tclin
Family:  Enzyme
Novelty:  0.00026112
Score:  0.995
Data Source:  STRINGDB
CTSG
Tchem
Family:  Enzyme
Novelty:  0.00102052
Score:  0.989
Data Source:  STRINGDB
RNASE3
Tbio
Family:  Enzyme
Novelty:  0.00059878
Score:  0.985
Data Source:  STRINGDB
AZU1
Tbio
Family:  Enzyme
Novelty:  0.00267169
Score:  0.985
Data Source:  STRINGDB
BPI
Tbio
Novelty:  0.00229665
Score:  0.983
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (15)
Events associated with phagocytolytic activity of PMN cells (R-HSA-8941413)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Events associated with phagocytolytic activity of PMN cells
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Reactome
ROS and RNS production in phagocytes
Name
Explore in Pharos
Explore in Source
Events associated with phagocytolytic activity of PMN cells
Immune System
Innate Immune System
Neutrophil degranulation
ROS and RNS production in phagocytes
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (27)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
7
8
98.6
neutrophil count
2
4
4
96.5
myeloperoxidase measurement
2
3
3
95.8
neutrophil percentage of leukocytes
2
4
5
93.4
leukocyte count
2
3
3
93.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
8
98.6
neutrophil count
4
96.5
myeloperoxidase measurement
3
95.8
neutrophil percentage of leukocytes
5
93.4
leukocyte count
3
93.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
myeloperoxidase
VGNC:9442
748680
Macaque
myeloperoxidase
714246
Mouse
MGI:97137
17523
Dog
myeloperoxidase
VGNC:43341
609986
Horse
myeloperoxidase
VGNC:20288
100070920
Species
Name
OMA
EggNOG
Inparanoid
Chimp
myeloperoxidase
Macaque
myeloperoxidase
Mouse
Dog
myeloperoxidase
Horse
myeloperoxidase
Publication Statistics
PubMed Score 4857.81
PubMed score by year
PubTator Score 5992.76
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title