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Tbio
MPIG6B
Megakaryocyte and platelet inhibitory receptor G6b

Protein Summary
Description
Inhibitory receptor that acts as a critical regulator of hematopoietic lineage differentiation, megakaryocyte function and platelet production (PubMed:12665801, PubMed:17311996, PubMed:27743390). Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide (PubMed:12665801). This regulation of megakaryocate function as well as platelet production ann activation is done through the inhibition (via the 2 ITIM motifs) of the receptors CLEC1B and GP6:FcRgamma signaling (PubMed:17311996). Appears to operate in a calcium-independent manner (PubMed:12665801). Isoform B, displayed in this entry, is the only isoform to contain both a transmembrane region and 2 immunoreceptor tyrosine-based inhibitor motifs (ITIMs) and, thus, the only one which probably has a role of inhibitory receptor. Isoform A may be the activating counterpart of isoform B. This gene is a member of the immunoglobulin (Ig) superfamily and is located in the major histocompatibility complex ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375804
  • ENSP00000364962
  • ENSG00000204420
  • ENST00000375805
  • ENSP00000364963
  • ENST00000375806
  • ENSP00000364964
  • ENST00000375809
  • ENSP00000364967
  • ENST00000375810
  • ENSP00000364968
  • ENST00000375814
  • ENSP00000364972
  • ENST00000383410
  • ENSP00000372902
  • ENSG00000206396
  • ENST00000383411
  • ENSP00000372903
  • ENST00000383412
  • ENSP00000372904
  • ENST00000400067
  • ENSP00000382940
  • ENST00000400071
  • ENSP00000382944
  • ENST00000411608
  • ENSP00000392961
  • ENSG00000228090
  • ENST00000415728
  • ENSP00000408430
  • ENSG00000224393
  • ENST00000415984
  • ENSP00000394082
  • ENSG00000237459
  • ENST00000417610
  • ENSP00000412747
  • ENSG00000230060
  • ENST00000422012
  • ENSP00000398061
  • ENST00000425998
  • ENSP00000392917
  • ENST00000426729
  • ENSP00000390272
  • ENST00000428302
  • ENSP00000404519
  • ENSG00000231003
  • ENST00000431888
  • ENSP00000390821
  • ENST00000433769
  • ENSP00000413647
  • ENST00000435007
  • ENSP00000401892
  • ENST00000436030
  • ENSP00000406706
  • ENST00000437153
  • ENSP00000412937
  • ENST00000440063
  • ENSP00000388982
  • ENST00000444404
  • ENSP00000415282
  • ENST00000445381
  • ENSP00000396823
  • ENST00000447587
  • ENSP00000416447
  • ENST00000449633
  • ENSP00000388484
  • ENST00000451549
  • ENSP00000395801
  • ENST00000455185
  • ENSP00000414824
  • ENST00000457450
  • ENSP00000395279
  • ENST00000457884
  • ENSP00000391097
  • ENST00000649779
  • ENSP00000497720

Symbol
  • C6orf25
  • G6B
  • G6B-B
  • G6b
  • NG31
  • G6b-B
  • THAMY
  • C6orf25
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.54   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 76   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.54   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (36)
PTPN11
Tchem
Family:  Enzyme
Novelty:  0.00073124
Score:  0.972
Data Source:  Reactome,STRINGDB
SYK
Tclin
Family:  Kinase
Novelty:  0.00058994
Score:  0.954
Data Source:  STRINGDB
GP6
Tchem
Novelty:  0.0010722
Score:  0.954
Data Source:  STRINGDB
CLEC1B
Tbio
Novelty:  0.00801736
Score:  0.945
Data Source:  STRINGDB
FYN
Tclin
Family:  Kinase
Novelty:  0.00072167
Score:  0.944
Data Source:  STRINGDB
PTPN6
Tchem
Family:  Enzyme
Novelty:  0.00535749
Score:  0.926
Data Source:  Reactome,STRINGDB
FCER1G
Tbio
Novelty:  0.00783146
Score:  0.921
Data Source:  STRINGDB
PDPN
Tbio
Novelty:  0.00024118
Score:  0.911
Data Source:  STRINGDB
LYN
Tclin
Family:  Kinase
Novelty:  0.00097393
Score:  0.908
Data Source:  STRINGDB
LY6G6F
Tbio
Novelty:  0.11261229
Score:  0.67
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (546)
Items per page:
1 – 5 of 546
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
3
0
3
96.5
1
3
0
3
96.5
1
3
0
3
96.5
1
3
0
3
96.5
1
3
0
3
96.5
Items per page:
1 – 5 of 546
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
3
96.5
0
3
96.5
0
3
96.5
0
3
96.5
0
3
96.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Publication Statistics
PubMed Score 30.54
PubMed score by year
PubTator Score 40.42
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title