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Tchem
MPG
DNA-3-methyladenine glycosylase

Protein Summary
Description
Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000219431
  • ENSP00000219431
  • ENSG00000103152
  • ENST00000356432
  • ENSP00000348809
  • ENST00000397817
  • ENSP00000380918

Symbol
  • AAG
  • ANPG
  • MID1
  • AAG
  • MDG
  • ADPG
  • APNG
  • Mid1
  • anpg
  • PIG11
  • PIG16
  • CRA36.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.93
interacting protein
0.82
transcription factor binding site profile
0.68
molecular function
0.67
kinase perturbation
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 360.25   (req: < 5)
Gene RIFs: 50   (req: <= 3)
Antibodies: 389   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 360.25   (req: >= 5)
Gene RIFs: 50   (req: > 3)
Antibodies: 389   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0