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Tbio
MOSPD2
Motile sperm domain-containing protein 2

Protein Summary
Description
Promotes migration of primary monocytes and neutrophils, in response to various chemokines.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380492
  • ENSP00000369860
  • ENSG00000130150
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.93
interacting protein
0.85
histone modification site profile
0.84
virus perturbation
0.83
disease perturbation
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.09   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 78   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.09   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 78   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (153)
LSMEM2
Tdark
Novelty:  43
p_int:  0.999999986
p_ni:  1.4e-8
Data Source:  BioPlex
PEX19
Tbio
Novelty:  0.00605342
p_int:  0.999998319
p_ni:  0.000001681
Data Source:  BioPlex
GNG2
Tbio
Novelty:  0.04807242
p_int:  0.999993042
p_ni:  0.000006958
p_wrong:  1e-9
Data Source:  BioPlex
FAM187B
Tdark
Novelty:  0.59092623
p_int:  0.99998349
p_ni:  0.00001651
Score:  0.175
Data Source:  BioPlex,STRINGDB
STX12
Tbio
Novelty:  0.03836262
p_int:  0.999237249
p_ni:  0.000762744
p_wrong:  6e-9
Data Source:  BioPlex
VAPA
Tbio
Novelty:  0.00169209
p_int:  0.998909712
p_ni:  0.001090287
p_wrong:  1e-9
Score:  0.278
Data Source:  BioPlex,STRINGDB
TGFA
Tbio
Novelty:  0.00216159
p_int:  0.998629952
p_ni:  0.001370048
Data Source:  BioPlex
OR13J1
Tdark
Family:  oGPCR
Novelty:  2.15311005
p_int:  0.998144036
p_ni:  0.001855964
Data Source:  BioPlex
PALM2
Tbio
Novelty:  0.03469098
p_int:  0.998126851
p_ni:  0.001870102
p_wrong:  0.000003046
Score:  0.169
Data Source:  BioPlex,STRINGDB
GNG4
Tbio
Novelty:  0.14371438
p_int:  0.997302626
p_ni:  0.002697222
p_wrong:  1.52e-7
Score:  0.179
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
1
1
2
55.2
lymphocyte percentage of leukocytes
1
1
1
54.4
neutrophil percentage of leukocytes
1
1
1
42.3
neutrophil count
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
2
55.2
lymphocyte percentage of leukocytes
1
54.4
neutrophil percentage of leukocytes
1
42.3
neutrophil count
1
35
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
motile sperm domain containing 2
VGNC:1508
465505
Macaque
motile sperm domain containing 2
712225
Mouse
MGI:1924013
76763
Rat
RGD:1563952
363463
Dog
motile sperm domain containing 2
VGNC:43325
491747
Species
Name
OMA
EggNOG
Inparanoid
Chimp
motile sperm domain containing 2
Macaque
motile sperm domain containing 2
Mouse
Rat
Dog
motile sperm domain containing 2
Publication Statistics
PubMed Score 7.09
PubMed score by year
PubTator Score 2.13
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title