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Tbio
MON1B
Vacuolar fusion protein MON1 homolog B

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000248248
  • ENSP00000248248
  • ENSG00000103111
  • ENST00000545553
  • ENSP00000444881

Symbol
  • HSRG1
  • KIAA0872
  • SAND2
  • SRG1
  • HSRG1
  • SAND2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.93
transcription factor binding site profile
0.87
histone modification site profile
0.84
small molecule perturbation
0.68
tissue sample
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.04   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 83   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.04   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (68)
KIF16B
Tbio
Novelty:  0.06703876
p_int:  1
Score:  0.519
Data Source:  BioPlex,STRINGDB
RNF181
Tbio
Family:  Enzyme
Novelty:  0.27482636
p_int:  0.999999491
p_ni:  5.03e-7
p_wrong:  6e-9
Data Source:  BioPlex
STRIP2
Tbio
Novelty:  0.19321125
p_int:  0.999813409
p_ni:  0.000178526
p_wrong:  0.000008066
Data Source:  BioPlex
CDC42EP3
Tbio
Novelty:  0.00908722
p_int:  0.99977508
p_ni:  0.000220709
p_wrong:  0.000004211
Data Source:  BioPlex
RAB7A
Tchem
Family:  Enzyme
Novelty:  0.00192702
Score:  0.995
Data Source:  STRINGDB
CCZ1
Tbio
Novelty:  0.09830652
Score:  0.995
Data Source:  STRINGDB
CCZ1B
Tdark
Novelty:  0.09724624
Score:  0.995
Data Source:  STRINGDB
RAB7B
Tbio
Family:  Enzyme
Novelty:  0.00207354
Score:  0.989
Data Source:  STRINGDB
GDI2
Tbio
Novelty:  0.02861013
Score:  0.947
Data Source:  STRINGDB
GDI1
Tbio
Novelty:  0.01710945
Score:  0.943
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Membrane Trafficking (R-HSA-199991)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Membrane Trafficking
Reactome
RAB GEFs exchange GTP for GDP on RABs
Reactome
Rab regulation of trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Membrane Trafficking
RAB GEFs exchange GTP for GDP on RABs
Rab regulation of trafficking
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cortical surface area measurement
2
1
0
6.4
86.8
brain measurement
1
1
0
14.1
73.8
cortical thickness
1
1
0
10.2
67
total cortical area measurement
2
2
2
35.8
body weight
1
1
1
20.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cortical surface area measurement
0
6.4
86.8
brain measurement
0
14.1
73.8
cortical thickness
0
10.2
67
total cortical area measurement
2
35.8
body weight
1
20.5
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
MON1 homolog B, secretory trafficking associated
VGNC:5841
468124
Macaque
MON1 homolog B, secretory trafficking associated
715104
Mouse
MGI:1923231
270096
Rat
RGD:1309977
307868
Dog
MON1 homolog B, secretory trafficking associated
VGNC:43314
489705
Species
Name
OMA
EggNOG
Inparanoid
Chimp
MON1 homolog B, secretory trafficking associated
Macaque
MON1 homolog B, secretory trafficking associated
Mouse
Rat
Dog
MON1 homolog B, secretory trafficking associated
Publication Statistics
PubMed Score 13.04
PubMed score by year
PubTator Score 9.28
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title