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Tbio
MOK
MAPK/MAK/MRK overlapping kinase

Protein Summary
Description
Able to phosphorylate several exogenous substrates and to undergo autophosphorylation. Negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner. This gene belongs to the MAP kinase superfamily. The gene was found to be regulated by caudal type transcription factor 2 (Cdx2) protein. The encoded protein, which is localized to epithelial cells in the intestinal crypt, may play a role in growth arrest and differentiation of cells of upper crypt and lower villus regions. Multiple alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Dec 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361847
  • ENSP00000355304
  • ENSG00000080823
  • ENST00000522874
  • ENSP00000429469
  • ENST00000524214
  • ENSP00000428942

Symbol
  • RAGE
  • RAGE1
  • RAGE
  • RAGE1
  • STK30
  • RAGE-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.93
cell type or tissue
0.74
protein domain
0.73
tissue sample
0.64
tissue
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.44   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 372   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.44   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 372   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (28)
CAMK2D
Tchem
Family:  Kinase
Novelty:  0.02326864
p_int:  0.999463008
p_ni:  0.000005198
p_wrong:  0.000531793
Data Source:  BioPlex
PNPO
Tchem
Family:  Enzyme
Novelty:  0.00919993
p_int:  0.999247511
p_ni:  0.000537138
p_wrong:  0.00021535
Score:  0.534
Data Source:  BioPlex,STRINGDB
HIST1H1D
Tbio
Novelty:  0.00922175
p_int:  0.998700899
p_ni:  0.001299062
p_wrong:  3.9e-8
Score:  0.317
Data Source:  BioPlex,STRINGDB
IMPDH1
Tclin
Family:  Enzyme
Novelty:  0.00758575
p_int:  0.998294874
p_ni:  0.000003676
p_wrong:  0.001701449
Data Source:  BioPlex
NAA50
Tchem
Family:  Enzyme
Novelty:  0.01843508
p_int:  0.763685784
p_ni:  0.2363084
p_wrong:  0.000005816
Score:  0.28
Data Source:  BioPlex,STRINGDB
MBP
Tbio
Novelty:  0.00016333
Score:  0.901
Data Source:  STRINGDB
ZNF239
Tbio
Family:  TF
Novelty:  0.09880652
Score:  0.705
Data Source:  STRINGDB
TSN
Tbio
Novelty:  0.00510474
Score:  0.654
Data Source:  STRINGDB
MAGEA1
Tbio
Novelty:  0.00506874
Score:  0.645
Data Source:  STRINGDB
SNRPE
Tbio
Novelty:  0.02033423
Score:  0.622
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
4
4
96.2
urate measurement
2
2
2
74
platelet count
1
1
1
50.6
reticulocyte count
2
1
2
47.7
platelet crit
1
1
1
42.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
96.2
urate measurement
2
74
platelet count
1
50.6
reticulocyte count
2
47.7
platelet crit
1
42.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
MOK protein kinase
VGNC:3380
453176
Mouse
MGI:1336881
26448
Rat
RGD:1309274
362787
Dog
MOK protein kinase
VGNC:43312
490863
Horse
MOK protein kinase
VGNC:20258
100058407
Species
Name
OMA
EggNOG
Inparanoid
Chimp
MOK protein kinase
Mouse
Rat
Dog
MOK protein kinase
Horse
MOK protein kinase
Publication Statistics
PubMed Score 83.44
PubMed score by year
PubTator Score 66.87
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title