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Tbio
MOGS
Mannosyl-oligosaccharide glucosidase

Protein Summary
Description
Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor in a highly specific manner. This gene encodes the first enzyme in the N-linked oligosaccharide processing pathway. The enzyme cleaves the distal alpha-1,2-linked glucose residue from the Glc(3)-Man(9)-GlcNAc(2) oligosaccharide precursor. This protein is located in the lumen of the endoplasmic reticulum. Defects in this gene are a cause of type IIb congenital disorder of glycosylation (CDGIIb). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000233616
  • ENSP00000233616
  • ENSG00000115275
  • ENST00000448666
  • ENSP00000410992
  • ENST00000452063
  • ENSP00000388201

Symbol
  • GCS1
  • DER7
  • GCS1
  • CDG2B
  • CWH41
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
disease perturbation
0.93
cellular component
0.76
hub protein
0.71
kinase perturbation
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 184.91   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 174   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 184.91   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 174   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (118)
RRP1
Tbio
Novelty:  0.12984245
p_int:  0.999967543
p_ni:  0.000032457
Data Source:  BioPlex
KPNB1
Tbio
Novelty:  0.01469696
p_int:  0.790288915
p_ni:  0.209711085
Data Source:  BioPlex
HSPA5
Tchem
Novelty:  0.00043424
p_int:  0.767350733
p_ni:  0.232649267
Score:  0.387
Data Source:  BioPlex,STRINGDB
HLA-DQB1
Tbio
Novelty:  0.00197952
p_int:  0.765207067
p_ni:  0.234792933
Data Source:  BioPlex
CD1A
Tbio
Novelty:  0.00090676
p_int:  0.762181634
p_ni:  0.237818366
Data Source:  BioPlex
SCGB2A1
Tbio
Novelty:  0.01902973
p_int:  0.760198518
p_ni:  0.239801482
Data Source:  BioPlex
GANAB
Tchem
Family:  Enzyme
Novelty:  0.01211958
Score:  0.994
Data Source:  STRINGDB
DDOST
Tchem
Family:  Enzyme
Novelty:  0.01797594
Score:  0.969
Data Source:  STRINGDB
RPN1
Tbio
Family:  Enzyme
Novelty:  0.00880101
Score:  0.969
Data Source:  STRINGDB
TUSC3
Tbio
Novelty:  0.01388722
Score:  0.964
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (13)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Defective MOGS causes MOGS-CDG (CDG-2b)
Reactome
Disease
Reactome
Diseases associated with N-glycosylation of proteins
Reactome
Diseases of glycosylation
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Defective MOGS causes MOGS-CDG (CDG-2b)
Disease
Diseases associated with N-glycosylation of proteins
Diseases of glycosylation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
1
1
64.9
body height
1
1
1
59.9
platelet crit
1
1
1
59
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
64.9
body height
1
59.9
platelet crit
1
59
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mannosyl-oligosaccharide glucosidase
VGNC:323
740472
Macaque
mannosyl-oligosaccharide glucosidase
708913
Mouse
MGI:1929872
57377
Rat
RGD:69240
78947
Dog
mannosyl-oligosaccharide glucosidase
VGNC:43311
483104
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mannosyl-oligosaccharide glucosidase
Macaque
mannosyl-oligosaccharide glucosidase
Mouse
Rat
Dog
mannosyl-oligosaccharide glucosidase
Publication Statistics
PubMed Score 184.91
PubMed score by year
PubTator Score 88.68
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title