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Tchem
MOGAT2
2-acylglycerol O-acyltransferase 2

Protein Summary
Description
Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Has a preference toward monoacylglycerols containing unsaturated fatty acids in an order of C18:3 > C18:2 > C18:1 > C18:0. Plays a central role in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. May play a role in diet-induced obesity. The protein encoded by this gene is an enzyme that catalyzes the synthesis of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. The encoded protein is important in the uptake of dietary fat by the small intestine. This protein forms a complex with diacylglycerol O-acyltransferase 2 in the endoplasmic reticulum, and this complex catalyzes the synthesis of triacylglycerol. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000198801
  • ENSP00000198801
  • ENSG00000166391
  • ENST00000525093
  • ENSP00000436537
  • ENST00000526712
  • ENSP00000436283

Symbol
  • DC5
  • DGAT2L5
  • hDC5
  • MGAT2
  • DGAT2L5
  • DGAT2L5.
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
metabolite
1
gene perturbation
0.81
cell line
0.6
PubMedID
0.54
virus perturbation
0.5


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.72   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 137   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.72   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 137   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 172
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (172)
CHEMBL2376303
Rendered image for CHEMBL2376303
CHEMBL3325734,CHEMBL3545611
Rendered image for CHEMBL3325734,CHEMBL3545611
CHEMBL2441600
Rendered image for CHEMBL2441600
BDBM152808::US8993568, 2
Rendered image for BDBM152808::US8993568, 2
CHEMBL2441599
Rendered image for CHEMBL2441599
CHEMBL2441597
Rendered image for CHEMBL2441597
US9035059, 19-4
Rendered image for US9035059, 19-4
CHEMBL3134097
Rendered image for CHEMBL3134097
US9035059, 19-3
Rendered image for US9035059, 19-3
CHEMBL3655064
Rendered image for CHEMBL3655064
Protein-Protein Interactions (77)
NME2P1
Tdark
Family:  Kinase
p_int:  0.99393344
p_ni:  0.006066316
p_wrong:  2.44e-7
Data Source:  BioPlex
DDI2
Tbio
Novelty:  0.09288646
p_int:  0.94888187
p_ni:  0.05111813
Data Source:  BioPlex
DGAT1
Tclin
Family:  Enzyme
Novelty:  0.00121009
Score:  0.99
Data Source:  STRINGDB
MGLL
Tchem
Family:  Enzyme
Novelty:  0.00196912
Score:  0.95
Data Source:  STRINGDB
PLPP4
Tbio
Family:  Enzyme
Novelty:  0.22418589
Score:  0.915
Data Source:  STRINGDB
PLPP5
Tbio
Family:  Enzyme
Novelty:  0.14757412
Score:  0.915
Data Source:  STRINGDB
AGK
Tbio
Family:  Enzyme
Novelty:  0.00919083
Score:  0.911
Data Source:  STRINGDB
MOGAT3
Tbio
Family:  Enzyme
Novelty:  0.13895233
Score:  0.908
Data Source:  STRINGDB
DGAT2
Tchem
Family:  Enzyme
Novelty:  0.00488581
Score:  0.906
Data Source:  STRINGDB
LPL
Tchem
Family:  Enzyme
Novelty:  0.00057058
Score:  0.904
Data Source:  STRINGDB
Nearest Tclin Targets (6)
Explore Nearest Tclin Targets
1 – 3 of 3
LIPF
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
DGAT1
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
PNLIP
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
Pathways (8)
Metabolism (R-HSA-1430728)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Triglyceride biosynthesis
Reactome
Triglyceride metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
Triglyceride biosynthesis
Triglyceride metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (48)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
39
12
42
97.6
total cholesterol measurement
8
4
8
92.8
vitamin D measurement
3
3
3
88.8
fatty acid measurement
7
6
7
86.7
phosphatidylcholine measurement
10
7
2
6.8
86.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
42
97.6
total cholesterol measurement
8
92.8
vitamin D measurement
3
88.8
fatty acid measurement
7
86.7
phosphatidylcholine measurement
2
6.8
86.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
monoacylglycerol O-acyltransferase 2
696347
Mouse
MGI:2663253
233549
Rat
RGD:1598060
681211
Dog
monoacylglycerol O-acyltransferase 2
VGNC:43309
485186
Horse
monoacylglycerol O-acyltransferase 2
VGNC:20256
100064445
Species
Name
OMA
EggNOG
Inparanoid
Macaque
monoacylglycerol O-acyltransferase 2
Mouse
Rat
Dog
monoacylglycerol O-acyltransferase 2
Horse
monoacylglycerol O-acyltransferase 2
Publication Statistics
PubMed Score 19.72
PubMed score by year
PubTator Score 15.89
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title