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Tbio
MOCS3
Adenylyltransferase and sulfurtransferase MOCS3

Protein Summary
Description
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions. Molybdenum cofactor (MoCo) is necessary for the function of all molybdoenzymes. The protein encoded by this gene adenylates and activates molybdopterin synthase, an enzyme required for bi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000244051
  • ENSP00000244051
  • ENSG00000124217

Symbol
  • UBA4
  • UBA4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
histone modification site profile
0.92
protein domain
0.85
cell type or tissue
0.72
tissue sample
0.67


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.22   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 168   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.22   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 168   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (126)
KLC2
Tbio
Novelty:  0.06284367
p_int:  0.999994607
p_ni:  0.000005393
Score:  0.234
Data Source:  BioPlex,STRINGDB
FBXL18
Tdark
Novelty:  0.33137957
p_int:  0.999566692
p_ni:  0.000433301
p_wrong:  7e-9
Score:  0.188
Data Source:  BioPlex,STRINGDB
HERC4
Tbio
Family:  Enzyme
Novelty:  0.06392683
p_int:  0.994583331
p_ni:  0.005385064
p_wrong:  0.000031605
Score:  0.219
Data Source:  BioPlex,STRINGDB
ALX3
Tbio
Family:  TF
Novelty:  0.02711914
p_int:  0.994175312
p_ni:  0.005824688
Score:  0.189
Data Source:  BioPlex,STRINGDB
RSPH9
Tbio
Novelty:  0.08651313
p_int:  0.976816471
p_ni:  0.023183529
Score:  0.187
Data Source:  BioPlex,STRINGDB
DYNC2H1
Tbio
Novelty:  0.01306616
p_int:  0.898231976
p_ni:  0.101768024
Score:  0.188
Data Source:  BioPlex,STRINGDB
SACS
Tbio
Novelty:  0.00443197
p_int:  0.847753601
p_ni:  0.14552504
p_wrong:  0.006721359
Score:  0.312
Data Source:  BioPlex,STRINGDB
POMK
Tbio
Family:  Kinase
Novelty:  0.09340344
p_int:  0.831656209
p_ni:  0.168343791
p_wrong:  1e-9
Data Source:  BioPlex
HSPA6
Tbio
Novelty:  0.00654285
p_int:  0.820818646
p_ni:  0.179181354
Score:  0.222
Data Source:  BioPlex,STRINGDB
VPS16
Tbio
Novelty:  0.03575558
p_int:  0.813766231
p_ni:  0.186233662
p_wrong:  1.07e-7
Score:  0.214
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of vitamins and cofactors
Reactome
Metabolism of water-soluble vitamins and cofactors
Reactome
Molybdenum cofactor biosynthesis
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of vitamins and cofactors
Metabolism of water-soluble vitamins and cofactors
Molybdenum cofactor biosynthesis
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (17)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
3
6
92
1
1
0
1.1
46.9
2
2
1
1.1
24.5
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
92
0
1.1
46.9
1
1.1
24.5
1
15.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
molybdenum cofactor synthesis 3
VGNC:14260
458338
Macaque
molybdenum cofactor synthesis 3
701166
Mouse
MGI:1916622
69372
Rat
RGD:1307044
311655
Dog
molybdenum cofactor synthesis 3
VGNC:43307
485928
Species
Name
OMA
EggNOG
Inparanoid
Chimp
molybdenum cofactor synthesis 3
Macaque
molybdenum cofactor synthesis 3
Mouse
Rat
Dog
molybdenum cofactor synthesis 3
Publication Statistics
PubMed Score 24.22
PubMed score by year
PubTator Score 9.01
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title