Tclin MOCS1 Molybdenum cofactor biosynthesis protein 1

Protein Summary

Description

Isoform MOCS1A and isoform MOCS1B probably form a complex that catalyzes the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP). MOCS1A catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate and MOCS1B catalyzes the subsequent conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cPMP. Molybdenum cofactor biosynthesis is a conserved pathway leading to the biological activation of molybdenum. The protein encoded by this gene is involved in this pathway. This gene was originally thought to produce a bicistronic mRNA with the potential to produce two proteins (MOCS1A and MOCS1B) from adjacent open reading frames. However, only the first open reading frame (MOCS1A) has been found to encode a protein from the putative bicistronic mRNA, whereas additional splice variants are likely to produce a fusion between the two open reading frames. This gene is defective in patients with molybdenum cofactor deficiency, type A. A related pseudogene has been identified on chromosome 16. [provided by RefSeq, Nov 2017]

Uniprot Accession IDs

• Q9NZB8
• B3KPT7
• B4DTP1
• O14940
• O14941
• O75710
• Q5J7W0
• Q5TCE1
• Q5TCE2
• Q5TCE6
• Q5TCE9
• Q5TCF0
• Q5TCF1
• Q8N418
• Q9NZB7
• Q9UEM1

Gene Name

• MOCS1

Ensembl ID

• ENST00000340692
• ENSP00000344794
• ENSG00000124615
• ENST00000373181
• ENSP00000362277
• ENST00000373188
• ENSP00000362284
• ENST00000373195
• ENSP00000362291

Symbol

• MIG11
• MOCOD
• MOCS1A
• MOCS1B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.99
molecular function	0.93
pathway	0.78
cell type or tissue	0.69
microRNA	0.64

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.48   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 180   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.48   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 180   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1