Tbio MOCOS Molybdenum cofactor sulfurase

Protein Summary

Description

Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form. In vitro, the C-terminal domain is able to reduce N-hydroxylated prodrugs, such as benzamidoxime. This gene encodes an enzyme that sulfurates the molybdenum cofactor which is required for activation of the xanthine dehydrogenase (XDH) and aldehyde oxidase (AO) enzymes. XDH catalyzes the conversion of hypoxanthine to uric acid via xanthine, as well as the conversion of allopurinol to oxypurinol, and pyrazinamide to 5-hydroxy pyrazinamide. Mutations in this gene cause the metabolic disorder classical xanthinuria type II which is characterized by the loss of XDH/XO and AO enzyme activity, decreased levels of uric acid in the urine, increased levels of xanthine and hypoxanthine in the serum and urine, formation of xanthine stones in the urinary tract, and myositis due to tissue deposition of xanthine. [provided by RefSeq, Apr 2017]

Uniprot Accession IDs

• Q96EN8
• Q53GP5
• Q8N3A4
• Q9NWM7
• MCS

Gene Name

• MOCOS

Ensembl ID

• ENST00000261326
• ENSP00000261326
• ENSG00000075643

Symbol

• MCS
• MOS
• HMCS

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.97
virus perturbation	0.97
histone modification site profile	0.86
disease perturbation	0.74
gene perturbation	0.73

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.88   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 43   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.88   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 43   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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ARCHS4

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (71)

Explore Interacting Targets

1 – 10 of 71

• See Interactions on String-DB

HSD17B8

Tbio

Family:  Enzyme

Novelty:  0.00915958

p_int:  0.999999558

p_ni:  4.41e-7

p_wrong:  1e-9

Score:  0.224

Data Source:  BioPlex,STRINGDB

PARVA

Tbio

Novelty:  0.02736601

p_int:  0.999984208

p_ni:  0.000015776

p_wrong:  1.5e-8

Score:  0.303

Data Source:  BioPlex,STRINGDB

HDAC7

Tclin

Family:  Epigenetic

Novelty:  0.00600484

p_int:  0.999952218

p_ni:  0.000047782

Data Source:  BioPlex

RAB27A

Tchem

Family:  Enzyme

Novelty:  0.00369416

p_int:  0.999906286

p_ni:  0.000093713

Data Source:  BioPlex

ARHGEF7

Tbio

Novelty:  0.00919946

p_int:  0.999870331

p_ni:  0.000129669

Data Source:  BioPlex

IFIT1B

Tdark

Novelty:  0.29249041

p_int:  0.999644651

p_ni:  0.000355327

p_wrong:  2.3e-8

Score:  0.21

Data Source:  BioPlex,STRINGDB

RGS20

Tbio

Novelty:  0.04087618

p_int:  0.997952585

p_ni:  0.002047357

p_wrong:  5.8e-8

Data Source:  BioPlex

ARL8A

Tbio

Family:  Enzyme

Novelty:  0.12499089

p_int:  0.99253642

p_ni:  0.007463548

p_wrong:  3.2e-8

Data Source:  BioPlex

IRF3

Tbio

Family:  TF

Novelty:  0.00099474

p_int:  0.990436916

p_ni:  0.009563083

Score:  0.173

Data Source:  BioPlex,STRINGDB

PLAU

Tchem

Family:  Enzyme

Novelty:  0.0005322

p_int:  0.976869943

p_ni:  0.02312786

p_wrong:  0.000002197

Score:  0.378

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (6)

Reactome (4)

KEGG (1)

PathwayCommons (1)

Metabolism (R-HSA-1430728)

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1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Metabolism of vitamins and cofactors	188 targets	R-HSA-196854
Reactome	Metabolism of water-soluble vitamins and cofactors	122 targets	R-HSA-196849
Reactome	Molybdenum cofactor biosynthesis	7 targets	R-HSA-947581

Name	Explore in Pharos	Explore in Source
Metabolism	2112 targets	R-HSA-1430728
Metabolism of vitamins and cofactors	188 targets	R-HSA-196854
Metabolism of water-soluble vitamins and cofactors	122 targets	R-HSA-196849
Molybdenum cofactor biosynthesis	7 targets	R-HSA-947581

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (9)

Functions (5)

Components (1)

Processes (3)

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1 – 5 of 5

GO Term	Evidence	Assigned by
Mo-molybdopterin cofactor sulfurase activity	Inferred from Mutant Phenotype (IMP)	UniProtKB
lyase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-UniRule
molybdenum cofactor sulfurtransferase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-EC
molybdenum ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-UniRule
pyridoxal phosphate binding	Inferred from Electronic Annotation (IEA)	UniProtKB-UniRule

Disease Associations ()

No disease associations found

GWAS Traits (3)

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1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
squamous cell carcinoma	EFO_0000707	1	1	0	1.3	15.8
esophageal carcinoma	EFO_0002916	1	1	0	1.3	15.8
survival time	EFO_0000714	1	1	0	1.3	15.8

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 3 of 3

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
squamous cell carcinoma	EFO_0000707	0	1.3	15.8
esophageal carcinoma	EFO_0002916	0	1.3	15.8
survival time	EFO_0000714	0	1.3	15.8

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Complete proteome
Disease mutation
Molybdenum cofactor biosynthesis
Phosphoprotein
Polymorphism
Pyridoxal phosphate
Reference proteome
Transferase

GWAS Trait Find Similar Targets

No Header	No Header
esophageal carcinoma
squamous cell carcinoma
survival time

IDG Resources

No IDG generated resources found

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	molybdenum cofactor sulfurase	VGNC:5186	455379
Macaque	molybdenum cofactor sulfurase		715633
Mouse	molybdenum cofactor sulfurase	MGI:1915841	68591
Rat	molybdenum cofactor sulfurase	RGD:1308496	361300
Dog	molybdenum cofactor sulfurase	VGNC:43305	490482

Species	Name	OMA	EggNOG	Inparanoid
Chimp	molybdenum cofactor sulfurase
Macaque	molybdenum cofactor sulfurase
Mouse	molybdenum cofactor sulfurase
Rat	molybdenum cofactor sulfurase
Dog	molybdenum cofactor sulfurase

Publication Statistics

PubMed Score 20.88

PubMed score by year

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PubTator Score 12.70

PubTator score by year

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Related Publications

Text Mined References (12)

GeneRif Annotations (3)

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10

0 of 0

PMID	Year	Title