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Tbio
MOB4
MOB-like protein phocein

Protein Summary
Description
May play a role in membrane trafficking, specifically in membrane budding reactions. This gene was identified based on its similarity with the mouse counterpart. Studies of the mouse counterpart suggest that the expression of this gene may be regulated during oocyte maturation and preimplantation following zygotic gene activation. Alternatively spliced transcript variants encoding distinct isoforms have been observed. Naturally occurring read-through transcription occurs between this locus and the neighboring locus HSPE1.[provided by RefSeq, Feb 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000233892
  • ENSP00000233892
  • ENSG00000115540
  • ENST00000323303
  • ENSP00000315702
  • ENST00000409360
  • ENSP00000387289
  • ENST00000448447
  • ENSP00000405354

Symbol
  • MOB3
  • MOBKL3
  • PHOCN
  • PREI3
  • 2C4D
  • MOB1
  • MOB3
  • PHOCN
  • PREI3
  • CGI-95
  • MOBKL3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.96
hub protein
0.92
transcription factor binding site profile
0.92
cell type or tissue
0.82
transcription factor perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.42   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 178   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.42   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 178   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (68)
STRN
Tbio
Novelty:  0.01025814
p_int:  0.999999886
p_ni:  8.3e-8
p_wrong:  3.1e-8
Score:  0.995
Data Source:  BioPlex,STRINGDB
STRN3
Tbio
Novelty:  0.10331283
p_int:  0.999999699
p_ni:  3.01e-7
Score:  0.96
Data Source:  BioPlex,STRINGDB
PPP2R1A
Tbio
Family:  Enzyme
Novelty:  0.01134139
p_int:  0.999982835
p_ni:  0.000017165
Score:  0.937
Data Source:  BioPlex,STRINGDB
TRAF3IP3
Tbio
Novelty:  0.12180834
p_int:  0.99996412
p_ni:  0.000005714
p_wrong:  0.000030166
Score:  0.892
Data Source:  BioPlex,STRINGDB
PIP
Tbio
Novelty:  0.00208509
p_int:  0.99930589
p_ni:  0.00068535
p_wrong:  0.00000876
Data Source:  BioPlex
PPP2CB
Tbio
Family:  Enzyme
Novelty:  0.0483178
p_int:  0.998987876
p_ni:  0.000021109
p_wrong:  0.000991015
Score:  0.891
Data Source:  BioPlex,STRINGDB
ISCA2
Tbio
Novelty:  0.02194373
p_int:  0.997821599
p_ni:  0.002178369
p_wrong:  3.2e-8
Data Source:  BioPlex
TNFRSF1A
Tchem
Novelty:  0.00037847
p_int:  0.997733217
p_ni:  0.002217506
p_wrong:  0.000049278
Data Source:  BioPlex
PRDM14
Tbio
Family:  TF; Epigenetic
Novelty:  0.01776592
p_int:  0.996593293
p_ni:  0.001416412
p_wrong:  0.001990294
Data Source:  BioPlex
AGA
Tbio
Family:  Enzyme
Novelty:  0.01522819
p_int:  0.994729012
p_ni:  0.004383292
p_wrong:  0.000887695
Score:  0.519
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
2
0
1
80.7
7
4
1
1.1
74.1
1
1
0
1
57.3
Eczema
1
1
0
1
57.3
1
2
0
1.1
52
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
0
1
80.7
1
1.1
74.1
0
1
57.3
Eczema
0
1
57.3
0
1.1
52
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:104899
19070
Pig
MOB family member 4, phocein
613127
Chicken
MOB family member 4, phocein
CGNC:53535
429007
Xenopus
MOB family member 4, phocein
XB-GENE-948291
549964
Zebrafish
ZDB-GENE-040801-174
445045
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Pig
MOB family member 4, phocein
Chicken
MOB family member 4, phocein
Xenopus
MOB family member 4, phocein
Zebrafish
Publication Statistics
PubMed Score 35.42
PubMed score by year
PubTator Score 7.07
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title