Tbio MOB1B MOB kinase activator 1B

Protein Summary

Description

Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L. The protein encoded by this gene is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

Uniprot Accession IDs

• Q7L9L4
• B2R8U6
• B4DRY3
• Q8IY23

Gene Name

• MOB1B

Ensembl ID

• ENST00000309395
• ENSP00000310189
• ENSG00000173542
• ENST00000396051
• ENSP00000379366

Symbol

• MOB4A
• MOBKL1A
• MATS2
• MOB4A
• MOBKL1A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.84
microRNA	0.76
interacting protein	0.75
histone modification site profile	0.71
virus perturbation	0.68

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / Kinase Modulator / Kinase Activator / Mob Kinase Activator 1b

DTO Classes

Protein / Enzyme Modulator / Kinase Modulator / Kinase Activator / Mob Kinase Activator 1b

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.69   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 332   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.69   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 332   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0