MOB1B
MOB kinase activator 1B
Protein Summary
Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L. The protein encoded by this gene is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
- ENST00000309395
- ENSP00000310189
- ENSG00000173542
- ENST00000396051
- ENSP00000379366
- MOB4A
- MOBKL1A
- MATS2
- MOB4A
- MOBKL1A
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor binding site profile | 0.84 | ||
microRNA | 0.76 | ||
interacting protein | 0.75 | ||
histone modification site profile | 0.71 | ||
virus perturbation | 0.68 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 11.45 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 332 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 11.45 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 332 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (61)
LATS1
Family: Kinase
Novelty: 0.00369058
p_int: 1
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
LATS2
Family: Kinase
Novelty: 0.00521035
p_int: 1
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
STK38
Family: Kinase
Novelty: 0.03242123
p_int: 0.999999446
p_ni: 5.52e-7
p_wrong: 1e-9
Score: 0.895
Data Source: BioPlex,STRINGDB
LRCH2
Novelty: 1.90908316
p_int: 0.999762932
p_ni: 0.000237068
Score: 0.229
Data Source: BioPlex,STRINGDB
DOCK7
Novelty: 0.03425586
p_int: 0.999698368
p_ni: 0.000301632
Score: 0.343
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (4)
Reactome (2)
KEGG (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Signal Transduction | ||||
Reactome | Signaling by Hippo | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Signal Transduction | ||||
Signaling by Hippo | ||||
Viral Interactions (0)
Gene Ontology Terms (10)
Functions (3)
Components (5)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
4 | 4 | 2 | 1.1 | 82 | |||||
viral load | 1 | 1 | 1 | 65.4 | |||||
mean corpuscular volume | 1 | 1 | 1 | 46.9 | |||||
red blood cell distribution width | 1 | 1 | 1 | 46.1 | |||||
mean reticulocyte volume | 1 | 1 | 1 | 45.7 | |||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
2 | 1.1 | 82 | |||||
viral load | 1 | 65.4 | |||||
mean corpuscular volume | 1 | 46.9 | |||||
red blood cell distribution width | 1 | 46.1 | |||||
mean reticulocyte volume | 1 | 45.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | MOB kinase activator 1B | VGNC:13028 | 741698 | |||||
Macaque | MOB kinase activator 1B | 705155 | ||||||
Mouse | MGI:1915723 | 68473 | ||||||
Rat | RGD:1305114 | 360920 | ||||||
Dog | MOB kinase activator 1B | VGNC:43300 | 482187 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | MOB kinase activator 1B | |||||
Macaque | MOB kinase activator 1B | |||||
Mouse | ||||||
Rat | ||||||
Dog | MOB kinase activator 1B | |||||
Publication Statistics
PubMed Score 11.45
PubMed score by year
PubTator Score 2.49
PubTator score by year
Related Publications
Text Mined References (14)
GeneRif Annotations (2)
Items per page:
0 of 0
PMID | Year | Title |
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