Tbio MNS1 Meiosis-specific nuclear structural protein 1

Protein Summary

Description

May play a role in the control of meiotic division and germ cell differentiation through regulation of pairing and recombination during meiosis. This gene encodes a protein highly similar to the mouse meiosis-specific nuclear structural 1 protein. The mouse protein was shown to be expressed at the pachytene stage during spermatogenesis and may function as a nuclear skeletal protein to regulate nuclear morphology during meiosis. [provided by RefSeq, Oct 2008]

Uniprot Accession IDs

• Q8NEH6
• Q8IYT6
• Q9NUP4

Gene Name

• MNS1

Ensembl ID

• ENST00000260453
• ENSP00000260453
• ENSG00000138587

Symbol

• SPATA40

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.75
transcription factor perturbation	0.68
cell line	0.66
tissue sample	0.65
gene perturbation	0.6

Protein Classes

PANTHER Classes

Protein / Structural Protein / Meiosis-specific Nuclear Structural Protein 1

DTO Classes

Protein / Cellular Structure / Meiosis-specific Nuclear Structural Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.7   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 88   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.7   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 88   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (56)

Explore Interacting Targets

1 – 10 of 56

• See Interactions on String-DB

FAM9B

Tdark

Novelty:  0.39508009

p_int:  0.999999969

p_ni:  2.6e-8

p_wrong:  5e-9

Data Source:  BioPlex

TUBGCP5

Tbio

Novelty:  0.04863776

Score:  0.893

Data Source:  STRINGDB

CFHR3

Tbio

Novelty:  0.01779009

Score:  0.887

Data Source:  STRINGDB

CFHR1

Tbio

Novelty:  0.00676665

Score:  0.875

Data Source:  STRINGDB

NIPA2

Tbio

Novelty:  0.05451663

Score:  0.816

Data Source:  STRINGDB

LMNB1

Tbio

Novelty:  0.00127348

Score:  0.8

Data Source:  STRINGDB

NIPA1

Tbio

Novelty:  0.02398766

Score:  0.769

Data Source:  STRINGDB

CYFIP1

Tbio

Novelty:  0.01758346

Score:  0.676

Data Source:  STRINGDB

MAN1B1

Tchem

Family:  Enzyme

Novelty:  0.01348112

Score:  0.669

Data Source:  STRINGDB

RIBC2

Tdark

Novelty:  0.0209935

Score:  0.665

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (10)

Functions (1)

Components (4)

Processes (5)

Find Similar Targets

Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
identical protein binding	Inferred from Direct Assay (IDA)	MGI

Disease Associations (null)

No disease associations found

GWAS Traits (6)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 6

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
waist-hip ratio	EFO_0004343	3	8	8		87.6
BMI-adjusted waist-hip ratio	EFO_0007788	5	7	10		86.7
BMI-adjusted waist circumference	EFO_0007789	1	4	4		82.6
chronic lymphocytic leukemia	EFO_0000095	3	3	0	1.4	82.1
red blood cell distribution width	EFO_0005192	2	2	2		75.7

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 6

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
waist-hip ratio	EFO_0004343	8		87.6
BMI-adjusted waist-hip ratio	EFO_0007788	10		86.7
BMI-adjusted waist circumference	EFO_0007789	4		82.6
chronic lymphocytic leukemia	EFO_0000095	0	1.4	82.1
red blood cell distribution width	EFO_0005192	2		75.7

Reset Zoom  Beta Count   Odds Ratio

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Coiled coil
Complete proteome
Meiosis
Nucleus
Phosphoprotein
Polymorphism
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
BMI-adjusted waist circumference
BMI-adjusted waist-hip ratio
chronic lymphocytic leukemia
red blood cell distribution width
waist circumference
waist-hip ratio

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
endocrine/exocrine gland phenotype
growth/size/body region phenotype
mortality/aging
nervous system phenotype
reproductive system phenotype
respiratory system phenotype

IDG Resources

No IDG generated resources found

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	meiosis specific nuclear structural 1	VGNC:3535	453462
Macaque	meiosis specific nuclear structural 1		699377
Mouse	meiosis-specific nuclear structural protein 1	MGI:107933	17427
Rat	meiosis-specific nuclear structural 1	RGD:1549718	363093
Dog	meiosis specific nuclear structural 1	VGNC:43297	478314

Species	Name	OMA	EggNOG	Inparanoid
Chimp	meiosis specific nuclear structural 1
Macaque	meiosis specific nuclear structural 1
Mouse	meiosis-specific nuclear structural protein 1
Rat	meiosis-specific nuclear structural 1
Dog	meiosis specific nuclear structural 1

Publication Statistics

PubMed Score 26.70

PubMed score by year

Reset Zoom

PubTator Score 9.96

PubTator score by year

Reset Zoom

Related Publications

Text Mined References (12)

GeneRif Annotations (4)

Items per page:

10

0 of 0

PMID	Year	Title