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Tbio
MNS1
Meiosis-specific nuclear structural protein 1

Protein Summary
Description
May play a role in the control of meiotic division and germ cell differentiation through regulation of pairing and recombination during meiosis. This gene encodes a protein highly similar to the mouse meiosis-specific nuclear structural 1 protein. The mouse protein was shown to be expressed at the pachytene stage during spermatogenesis and may function as a nuclear skeletal protein to regulate nuclear morphology during meiosis. [provided by RefSeq, Oct 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260453
  • ENSP00000260453
  • ENSG00000138587

Symbol
  • SPATA40
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.75
transcription factor perturbation
0.68
cell line
0.66
tissue sample
0.65
gene perturbation
0.6


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.7   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 88   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.7   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 88   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (56)
FAM9B
Tdark
Novelty:  0.39508009
p_int:  0.999999969
p_ni:  2.6e-8
p_wrong:  5e-9
Data Source:  BioPlex
TUBGCP5
Tbio
Novelty:  0.04863776
Score:  0.893
Data Source:  STRINGDB
CFHR3
Tbio
Novelty:  0.01779009
Score:  0.887
Data Source:  STRINGDB
CFHR1
Tbio
Novelty:  0.00676665
Score:  0.875
Data Source:  STRINGDB
NIPA2
Tbio
Novelty:  0.05451663
Score:  0.816
Data Source:  STRINGDB
LMNB1
Tbio
Novelty:  0.00127348
Score:  0.8
Data Source:  STRINGDB
NIPA1
Tbio
Novelty:  0.02398766
Score:  0.769
Data Source:  STRINGDB
CYFIP1
Tbio
Novelty:  0.01758346
Score:  0.676
Data Source:  STRINGDB
MAN1B1
Tchem
Family:  Enzyme
Novelty:  0.01348112
Score:  0.669
Data Source:  STRINGDB
RIBC2
Tdark
Novelty:  0.0209935
Score:  0.665
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
3
8
8
87.6
BMI-adjusted waist-hip ratio
5
7
10
86.7
BMI-adjusted waist circumference
1
4
4
82.6
3
3
0
1.4
82.1
red blood cell distribution width
2
2
2
75.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
8
87.6
BMI-adjusted waist-hip ratio
10
86.7
BMI-adjusted waist circumference
4
82.6
0
1.4
82.1
red blood cell distribution width
2
75.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
meiosis specific nuclear structural 1
VGNC:3535
453462
Macaque
meiosis specific nuclear structural 1
699377
Mouse
MGI:107933
17427
Rat
RGD:1549718
363093
Dog
meiosis specific nuclear structural 1
VGNC:43297
478314
Species
Name
OMA
EggNOG
Inparanoid
Chimp
meiosis specific nuclear structural 1
Macaque
meiosis specific nuclear structural 1
Mouse
Rat
Dog
meiosis specific nuclear structural 1
Publication Statistics
PubMed Score 26.70
PubMed score by year
PubTator Score 9.96
PubTator score by year
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Related Publications
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PMID
Year
Title