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Tbio
MNDA
Myeloid cell nuclear differentiation antigen

Protein Summary
Description
May act as a transcriptional activator/repressor in the myeloid lineage. Plays a role in the granulocyte/monocyte cell-specific response to interferon. Stimulates the DNA binding of the transcriptional repressor protein YY1. The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi-202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the 5-prime untranslated region, was significantly upregulated in human monocytes exposed to interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific respon ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368141
  • ENSP00000357123
  • ENSG00000163563

Symbol
  • PYHIN3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.79
biological process
0.72
tissue sample
0.55
cell line
0.48
cellular component
0.45


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.66   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 299   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.66   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 299   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (207)
PYCARD
Tbio
Novelty:  0.00719985
Score:  0.968
Data Source:  STRINGDB
LYZ
Tbio
Family:  Enzyme
Novelty:  0.00151342
Score:  0.956
Data Source:  STRINGDB
RNASE2
Tchem
Family:  Enzyme
Novelty:  0.00267471
Score:  0.952
Data Source:  STRINGDB
MPO
Tchem
Family:  Enzyme
Novelty:  0.00020698
Score:  0.937
Data Source:  STRINGDB
RETN
Tbio
Novelty:  0.00062517
Score:  0.934
Data Source:  STRINGDB
RNASE3
Tbio
Family:  Enzyme
Novelty:  0.00059878
Score:  0.93
Data Source:  STRINGDB
CPPED1
Tbio
Family:  Enzyme
Novelty:  0.10475831
Score:  0.928
Data Source:  STRINGDB
CTSG
Tchem
Family:  Enzyme
Novelty:  0.00102052
Score:  0.927
Data Source:  STRINGDB
ELANE
Tclin
Family:  Enzyme
Novelty:  0.00026112
Score:  0.924
Data Source:  STRINGDB
GCA
Tbio
Novelty:  0.01485875
Score:  0.917
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
granulocyte count
1
1
1
77.1
HbA1c measurement
1
1
1
10.3
CCL2 measurement
1
1
1
0.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
granulocyte count
1
77.1
HbA1c measurement
1
10.3
CCL2 measurement
1
0.6
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
myeloid cell nuclear differentiation antigen
VGNC:1323
469840
Macaque
myeloid cell nuclear differentiation antigen
719220
Dog
myeloid cell nuclear differentiation antigen
VGNC:53122
111089951
Horse
myeloid cell nuclear differentiation antigen
VGNC:50853
106783181
Species
Name
OMA
EggNOG
Inparanoid
Chimp
myeloid cell nuclear differentiation antigen
Macaque
myeloid cell nuclear differentiation antigen
Dog
myeloid cell nuclear differentiation antigen
Horse
myeloid cell nuclear differentiation antigen
Publication Statistics
PubMed Score 52.66
PubMed score by year
PubTator Score 38.22
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title