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Tbio
MND1
Meiotic nuclear division protein 1 homolog

Protein Summary
Description
Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis (By similarity). Stimulates both DMC1- and RAD51-mediated homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks. The product of the MND1 gene associates with HOP2 (MIM 608665) to form a stable heterodimeric complex that binds DNA and stimulates the recombinase activity of RAD51 (MIM 179617) and DMC1 (MIM 602721) (Chi et al., 2007 [PubMed 17639080]). Both the MND1 and HOP2 genes are indispensable for meiotic recombination.[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000240488
  • ENSP00000240488
  • ENSG00000121211

Symbol
  • GAJ
  • GAJ
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.92
transcription factor perturbation
0.91
transcription factor binding site profile
0.78
histone modification site profile
0.63
tissue sample
0.57


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.51   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 146   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.51   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 146   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (188)
PSMC3IP
Tbio
Novelty:  0.06621408
p_int:  0.999999999
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
MTERF4
Tbio
Novelty:  0.17764705
p_int:  0.999999494
p_ni:  5.01e-7
p_wrong:  5e-9
Score:  0.313
Data Source:  BioPlex,STRINGDB
NSUN4
Tbio
Family:  Enzyme
Novelty:  0.15593771
p_int:  0.999939673
p_ni:  0.000060325
p_wrong:  2e-9
Score:  0.188
Data Source:  BioPlex,STRINGDB
EIF1AD
Tdark
Novelty:  0.23915521
p_int:  0.999531241
p_ni:  1.1e-8
p_wrong:  0.000468747
Data Source:  BioPlex
ALOX5
Tclin
Family:  Enzyme
Novelty:  0.00062988
p_int:  0.99855887
p_ni:  5.56e-7
p_wrong:  0.001440573
Score:  0.185
Data Source:  BioPlex,STRINGDB
SPAG9
Tbio
Family:  Enzyme
Novelty:  0.00527315
p_int:  0.767818154
p_ni:  0.232181846
Score:  0.175
Data Source:  BioPlex,STRINGDB
RAD51
Tchem
Novelty:  0.00011516
Score:  0.999
Data Source:  STRINGDB
DMC1
Tbio
Novelty:  0.05445277
Score:  0.97
Data Source:  STRINGDB
BRCA1
Tchem
Novelty:  0.00011146
Score:  0.954
Data Source:  STRINGDB
BRCA2
Tbio
Novelty:  0.0002217
Score:  0.947
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Meiosis
Reactome
Meiotic recombination
Reactome
Reproduction
Name
Explore in Pharos
Explore in Source
Cell Cycle
Meiosis
Meiotic recombination
Reproduction
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
5
3
5
86.8
sex hormone-binding globulin measurement
5
2
5
81.1
reticulocyte measurement
2
2
2
72.1
mean corpuscular volume
1
1
1
69.4
alkaline phosphatase measurement
1
1
1
67.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
5
86.8
sex hormone-binding globulin measurement
5
81.1
reticulocyte measurement
2
72.1
mean corpuscular volume
1
69.4
alkaline phosphatase measurement
1
67.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
meiotic nuclear divisions 1
VGNC:13101
461550
Macaque
tripartite motif containing 2 [Source:HGNC Symbol;Acc:HGNC:15974]
Mouse
MGI:1924165
76915
Rat
RGD:1309007
295160
Dog
meiotic nuclear divisions 1
VGNC:43296
482653
Species
Name
OMA
EggNOG
Inparanoid
Chimp
meiotic nuclear divisions 1
Macaque
tripartite motif containing 2 [Source:HGNC Symbol;Acc:HGNC:15974]
Mouse
Rat
Dog
meiotic nuclear divisions 1
Publication Statistics
PubMed Score 48.51
PubMed score by year
PubTator Score 14.46
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title