Tbio MNAT1 CDK-activating kinase assembly factor MAT1

Protein Summary

Description

Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. The protein encoded by this gene, along with cyclin H and CDK7, forms the CDK-activating kinase (CAK) enzymatic complex. This complex activates several cyclin-associated kinases and can also associate with TFIIH to activate transcription by RNA polymerase II. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

Uniprot Accession IDs

• P51948
• G3V1U8
• Q15817
• Q6ICQ7

Gene Name

• MNAT1

Ensembl ID

• ENST00000261245
• ENSP00000261245
• ENSG00000020426
• ENST00000539616
• ENSP00000446437

Symbol

• CAP35
• MAT1
• RNF66
• MAT1
• TFB3
• CAP35
• RNF66

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.98
disease perturbation	0.97
transcription factor binding site profile	0.89
drug perturbation	0.87
protein domain	0.85

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Cdk-activating Kinase Assembly Factor Mat1

Protein / Enzyme Modulator / Kinase Modulator / Kinase Activator / Cdk-activating Kinase Assembly Factor Mat1

DTO Classes

Protein / Enzyme Modulator / Kinase Modulator / Kinase Activator / Cdk-activating Kinase Assembly Factor Mat1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.18   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 221   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.18   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 221   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0