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Tbio
MNAT1
CDK-activating kinase assembly factor MAT1

Protein Summary
Description
Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. The protein encoded by this gene, along with cyclin H and CDK7, forms the CDK-activating kinase (CAK) enzymatic complex. This complex activates several cyclin-associated kinases and can also associate with TFIIH to activate transcription by RNA polymerase II. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261245
  • ENSP00000261245
  • ENSG00000020426
  • ENST00000539616
  • ENSP00000446437

Symbol
  • CAP35
  • MAT1
  • RNF66
  • MAT1
  • TFB3
  • CAP35
  • RNF66
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.98
disease perturbation
0.97
transcription factor binding site profile
0.89
drug perturbation
0.87
protein domain
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.3   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 221   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.3   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 221   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (279)
CCNH
Tbio
Novelty:  0.00693072
p_int:  1
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
CDK7
Tchem
Family:  Kinase
Novelty:  0.00322814
p_int:  0.999999996
p_ni:  4e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
PI15
Tbio
Family:  Enzyme
Novelty:  0.02244161
p_int:  0.988625489
p_ni:  0.01137451
Data Source:  BioPlex
CNOT3
Tbio
Novelty:  0.02463568
p_int:  0.974409045
p_ni:  0.025590852
p_wrong:  1.03e-7
Data Source:  BioPlex
ERCC3
Tbio
Family:  Enzyme
Novelty:  0.00978601
p_int:  0.932155265
p_ni:  0.067844735
Score:  0.999
Data Source:  BioPlex,STRINGDB
ABLIM3
Tdark
Novelty:  0.28184092
p_int:  0.916421747
p_ni:  0.083574632
p_wrong:  0.00000362
Data Source:  BioPlex
SIRT6
Tchem
Family:  Epigenetic
Novelty:  0.00155366
p_int:  0.826807501
p_ni:  0.173192499
Score:  0.161
Data Source:  BioPlex,STRINGDB
ERCC2
Tchem
Family:  Enzyme
Novelty:  0.00240155
p_int:  0.823269031
p_ni:  0.176730969
Score:  0.999
Data Source:  BioPlex,STRINGDB
GTF2H3
Tbio
Novelty:  0.08168167
Score:  0.999
Data Source:  STRINGDB
GTF2H4
Tbio
Novelty:  0.03140561
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (77)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 60
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Cyclin A/B1/B2 associated events during G2/M transition
Reactome
Cyclin A:Cdk2-associated events at S phase entry
Reactome
Cyclin D associated events in G1
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Cyclin A/B1/B2 associated events during G2/M transition
Cyclin A:Cdk2-associated events at S phase entry
Cyclin D associated events in G1
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
2
2
88.5
appendicular lean mass
3
2
3
85.2
optic disc area measurement
1
1
1
53.7
1
1
1
35
1
1
0
1.1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
2
88.5
appendicular lean mass
3
85.2
optic disc area measurement
1
53.7
1
35
0
1.1
33.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
MNAT1, CDK activating kinase assembly factor
VGNC:8356
452954
Macaque
MNAT1, CDK activating kinase assembly factor
703905
Mouse
MGI:106207
17420
Rat
RGD:628874
266713
Dog
MNAT1, CDK activating kinase assembly factor
VGNC:43295
480346
Species
Name
OMA
EggNOG
Inparanoid
Chimp
MNAT1, CDK activating kinase assembly factor
Macaque
MNAT1, CDK activating kinase assembly factor
Mouse
Rat
Dog
MNAT1, CDK activating kinase assembly factor
Publication Statistics
PubMed Score 47.30
PubMed score by year
PubTator Score 31.65
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title