You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
MMS22L
Protein MMS22-like

Protein Summary
Description
Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork-associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA. The protein encoded by this gene forms a complex with tonsoku-like, DNA repair protein (TONSL), and this complex recognizes and repairs DNA double-strand breaks at sites of stalled or collapsed replication forks. The encoded protein also can bind with the histone-associated protein NFKBIL2 to help regulate the chromatin state at stalled replication forks. Finally, this gene appears to be overexpressed in most lung and esophageal cancers. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000275053
  • ENSP00000275053
  • ENSG00000146263

Symbol
  • C6orf167
  • C6orf167
  • dJ39B17.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.87
microRNA
0.75
kinase perturbation
0.71
cell line
0.6
cellular component
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.95   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 13   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.95   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 13   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (58)
H2AFX
Tbio
Novelty:  0.00048694
p_int:  0.999998215
p_ni:  0.000001785
Score:  0.241
Data Source:  BioPlex,STRINGDB
SSRP1
Tbio
Family:  TF
Novelty:  0.0143993
p_int:  0.999995817
p_ni:  0.000004182
Score:  0.777
Data Source:  BioPlex,STRINGDB
HIST1H2BA
Tbio
Novelty:  0.02431803
p_int:  0.999995722
p_ni:  0.000004278
Data Source:  BioPlex
ASF1B
Tbio
Novelty:  0.05716701
p_int:  0.999985045
p_ni:  0.000014955
Score:  0.696
Data Source:  BioPlex,STRINGDB
NCR3LG1
Tbio
Novelty:  0.02681936
p_int:  0.999739113
p_ni:  0.000260887
Data Source:  BioPlex
HIST1H4A
Tchem
Novelty:  0.00279614
p_int:  0.999620341
p_ni:  0.000379659
p_wrong:  1e-9
Score:  0.163
Data Source:  BioPlex,STRINGDB
HIST1H3A
Tbio
Novelty:  0.00991842
p_int:  0.999594935
p_ni:  0.000405064
p_wrong:  2e-9
Score:  0.249
Data Source:  BioPlex,STRINGDB
H2AFY2
Tbio
Novelty:  0.09948698
p_int:  0.999254751
p_ni:  0.000744845
p_wrong:  4.04e-7
Score:  0.15
Data Source:  BioPlex,STRINGDB
OPRM1
Tclin
Family:  GPCR
Novelty:  0.0003701
p_int:  0.9990965
p_ni:  0.000899655
p_wrong:  0.000003845
Data Source:  BioPlex
PVR
Tbio
Novelty:  0.00215811
p_int:  0.989545253
p_ni:  0.010158328
p_wrong:  0.000296419
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
3
3
3
78.9
smoking status measurement
2
2
2
55.8
gait measurement
1
1
1
42.3
anxiety measurement
1
1
1
26.1
physical activity measurement
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
3
78.9
smoking status measurement
2
55.8
gait measurement
1
42.3
anxiety measurement
1
26.1
physical activity measurement
1
17.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
MMS22 like, DNA repair protein
VGNC:7901
462893
Mouse
MGI:2684980
212377
Rat
RGD:1304693
313108
Dog
MMS22 like, DNA repair protein
VGNC:43294
481930
Horse
MMS22 like, DNA repair protein
VGNC:20241
100066022
Species
Name
OMA
EggNOG
Inparanoid
Chimp
MMS22 like, DNA repair protein
Mouse
Rat
Dog
MMS22 like, DNA repair protein
Horse
MMS22 like, DNA repair protein
Publication Statistics
PubMed Score 6.95
PubMed score by year
PubTator Score 3.71
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title