Tchem MMP9 Matrix metalloproteinase-9

Protein Summary

Description

May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P14780
• B2R7V9
• Q3LR70
• Q8N725
• Q9H4Z1
• Q9UCJ9
• Q9UCL1
• Q9UDK2
• MMP-9

Gene Name

• MMP9

Ensembl ID

• ENST00000372330
• ENSP00000361405
• ENSG00000100985

Symbol

• CLG4B
• GELB
• CLG4B
• MMP-9
• MANDP2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	1
chemical	1
protein domain	1
gene perturbation	0.99
biological process	0.97

Protein Classes

PANTHER Classes

Protein / ... / Metalloprotease / Matrix Metalloproteinase-9

DTO Classes

Protein / Enzyme / Protease / Metalloprotease / Matrix Metalloproteinase-9

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13042.42   (req: < 5)

Gene RIFs: 2910   (req: <= 3)

Antibodies: 1827   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13042.42   (req: >= 5)

Gene RIFs: 2910   (req: > 3)

Antibodies: 1827   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 34

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1906

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1