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Tchem
MMP7
Matrilysin

Protein Summary
Description
Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase. This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal hemopexin domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes on chromosome 11. This gene exhibits elevated expression levels in multiple human cancers. [provided by RefSeq, Jan ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260227
  • ENSP00000260227
  • ENSG00000137673

Symbol
  • MPSL1
  • PUMP1
  • MMP-7
  • MPSL1
  • PUMP-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
protein domain
0.92
gene perturbation
0.88
disease
0.69
chemical
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1317.56   (req: < 5)
Gene RIFs: 357   (req: <= 3)
Antibodies: 770   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1317.56   (req: >= 5)
Gene RIFs: 357   (req: > 3)
Antibodies: 770   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 224
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (180)
TNKS1BP1
Tbio
Family:  Enzyme
Novelty:  0.21682007
p_int:  0.999907035
p_ni:  0.000092965
Score:  0.759
Data Source:  BioPlex,STRINGDB
CNOT6
Tbio
Novelty:  0.03605299
p_int:  0.999445161
p_ni:  0.000554834
p_wrong:  4e-9
Score:  0.729
Data Source:  BioPlex,STRINGDB
CNOT2
Tbio
Novelty:  0.01886737
p_int:  0.999250981
p_ni:  0.000749019
Score:  0.663
Data Source:  BioPlex,STRINGDB
CNOT11
Tbio
Novelty:  0.01687183
p_int:  0.999208982
p_ni:  0.000791018
Score:  0.808
Data Source:  BioPlex,STRINGDB
CNOT3
Tbio
Novelty:  0.02463568
p_int:  0.998974995
p_ni:  0.001025005
Score:  0.729
Data Source:  BioPlex,STRINGDB
CNOT10
Tdark
Novelty:  0.30195594
p_int:  0.998372448
p_ni:  0.001627552
Score:  0.759
Data Source:  BioPlex,STRINGDB
CNOT6L
Tbio
Novelty:  0.06038336
p_int:  0.9983309
p_ni:  0.001669099
p_wrong:  1e-9
Score:  0.795
Data Source:  BioPlex,STRINGDB
CNOT9
Tbio
Novelty:  0.05592835
p_int:  0.995564127
p_ni:  0.004435873
Score:  0.561
Data Source:  BioPlex,STRINGDB
CNOT1
Tbio
Novelty:  0.00362753
p_int:  0.995200934
p_ni:  0.004799066
Score:  0.759
Data Source:  BioPlex,STRINGDB
CNOT8
Tbio
Novelty:  0.01700084
p_int:  0.99508596
p_ni:  0.00491404
Score:  0.542
Data Source:  BioPlex,STRINGDB
Pathways (19)
Activation of Matrix Metalloproteinases (R-HSA-1592389)

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Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of Matrix Metalloproteinases
Reactome
Assembly of collagen fibrils and other multimeric structures
Reactome
Collagen degradation
Reactome
Collagen formation
Reactome
Degradation of the extracellular matrix
Name
Explore in Pharos
Explore in Source
Activation of Matrix Metalloproteinases
Assembly of collagen fibrils and other multimeric structures
Collagen degradation
Collagen formation
Degradation of the extracellular matrix
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
CAFA
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
matrix metalloproteinase 7 measurement
1
4
4
90.1
matrix metalloproteinase 1 measurement
1
1
1
72.5
1
1
0
2.8
66.4
prostate specific antigen measurement
1
1
1
65.6
2
1
0
1.1
57.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
matrix metalloproteinase 7 measurement
4
90.1
matrix metalloproteinase 1 measurement
1
72.5
0
2.8
66.4
prostate specific antigen measurement
1
65.6
0
1.1
57.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
matrix metallopeptidase 7
VGNC:1103
451509
Macaque
matrix metallopeptidase 7
703072
Mouse
MGI:103189
17393
Rat
RGD:3100
25335
Dog
matrix metallopeptidase 7
VGNC:43288
489432
Species
Name
OMA
EggNOG
Inparanoid
Chimp
matrix metallopeptidase 7
Macaque
matrix metallopeptidase 7
Mouse
Rat
Dog
matrix metallopeptidase 7
Publication Statistics
PubMed Score 1317.56
PubMed score by year
PubTator Score 1053.16
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title