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Tchem
MMP3
Stromelysin-1

Protein Summary
Description
Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299855
  • ENSP00000299855
  • ENSG00000149968

Symbol
  • STMY1
  • SL-1
  • STMY
  • STR1
  • CHDS6
  • MMP-3
  • STMY1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
protein domain
1
gene perturbation
0.99
drug
0.86
disease
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2621.53   (req: < 5)
Gene RIFs: 512   (req: <= 3)
Antibodies: 1238   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2621.53   (req: >= 5)
Gene RIFs: 512   (req: > 3)
Antibodies: 1238   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1352
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (238)
MMP10
Tchem
Novelty:  0.00112113
p_int:  1
Score:  0.987
Data Source:  BioPlex,STRINGDB
APOE
Tbio
Novelty:  0.00005049
p_int:  0.999922274
p_ni:  0.000077208
p_wrong:  5.18e-7
Score:  0.821
Data Source:  BioPlex,STRINGDB
PTPRS
Tchem
Family:  Enzyme
Novelty:  0.00587115
p_int:  0.96521772
p_ni:  0.03478228
Score:  0.192
Data Source:  BioPlex,STRINGDB
NUCB1
Tchem
Novelty:  0.0040312
p_int:  0.95665298
p_ni:  0.043346914
p_wrong:  1.06e-7
Score:  0.768
Data Source:  BioPlex,STRINGDB
TIMP3
Tbio
Family:  Enzyme
Novelty:  0.00134742
p_int:  0.932437439
p_ni:  0.067468595
p_wrong:  0.000093966
Score:  0.871
Data Source:  BioPlex,STRINGDB
LTBP1
Tbio
Novelty:  0.00958396
p_int:  0.919478336
p_ni:  0.077518678
p_wrong:  0.003002986
Score:  0.647
Data Source:  BioPlex,STRINGDB
KIAA0319L
Tbio
Novelty:  0.02873675
p_int:  0.838294915
p_ni:  0.161679962
p_wrong:  0.000025123
Score:  0.169
Data Source:  BioPlex,STRINGDB
TIMP1
Tbio
Family:  Enzyme
Novelty:  0.00020986
Score:  0.989
Data Source:  STRINGDB
ACAN
Tbio
Novelty:  0.00033695
Score:  0.987
Data Source:  STRINGDB
PLG
Tclin
Family:  Enzyme
Novelty:  0.00004806
Score:  0.979
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (77)
Activation of Matrix Metalloproteinases (R-HSA-1592389)

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Find Similar Targets
Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of Matrix Metalloproteinases
Reactome
Assembly of collagen fibrils and other multimeric structures
Reactome
Collagen degradation
Reactome
Collagen formation
Reactome
Cytokine Signaling in Immune system
Name
Explore in Pharos
Explore in Source
Activation of Matrix Metalloproteinases
Assembly of collagen fibrils and other multimeric structures
Collagen degradation
Collagen formation
Cytokine Signaling in Immune system
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
6
15
15
98.5
matrix metalloproteinase 1 measurement
3
4
5
97.5
matrix metalloproteinase measurement
2
4
4
96.8
matrix metalloproteinase 12 measurement
1
3
3
87.9
macrophage metalloelastase measurement
1
1
1
72.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
15
98.5
matrix metalloproteinase 1 measurement
5
97.5
matrix metalloproteinase measurement
4
96.8
matrix metalloproteinase 12 measurement
3
87.9
macrophage metalloelastase measurement
1
72.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
matrix metallopeptidase 3
VGNC:1102
451511
Macaque
matrix metallopeptidase 3
703762
Mouse
MGI:97010
17392
Rat
RGD:621317
171045
Dog
matrix metallopeptidase 3 (stromelysin 1, progelatinase)
403445
Species
Name
OMA
EggNOG
Inparanoid
Chimp
matrix metallopeptidase 3
Macaque
matrix metallopeptidase 3
Mouse
Rat
Dog
matrix metallopeptidase 3 (stromelysin 1, progelatinase)
Publication Statistics
PubMed Score 2621.53
PubMed score by year
PubTator Score 1661.48
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title