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Tchem
MMP2
72 kDa type IV collagenase

Protein Summary
Description
Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues in association with MMP14. PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrinv/beta3 on the surface of blood vessels. Isoform 2: Mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by inducin ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000219070
  • ENSP00000219070
  • ENSG00000087245
  • ENST00000437642
  • ENSP00000394237
  • ENST00000543485
  • ENSP00000444143
  • ENST00000570308
  • ENSP00000461421

Symbol
  • CLG4A
  • CLG4
  • MONA
  • CLG4A
  • MMP-2
  • TBE-1
  • MMP-II
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
protein domain
1
kinase perturbation
0.91
PubMedID
0.81
disease
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8231.48   (req: < 5)
Gene RIFs: 1778   (req: <= 3)
Antibodies: 1510   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8231.48   (req: >= 5)
Gene RIFs: 1778   (req: > 3)
Antibodies: 1510   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2393
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0