You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
MMP19
Matrix metalloproteinase-19

Protein Summary
Description
Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin. This gene encodes a member of a family of proteins that are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded protein is secreted as an inactive proprotein, which is activated upon cleavage by extracellular proteases. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322569
  • ENSP00000313437
  • ENSG00000123342
  • ENST00000409200
  • ENSP00000386625
  • ENST00000552872
  • ENSP00000446776

Symbol
  • MMP18
  • RASI
  • CODA
  • MMP18
  • RASI-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
tissue sample
0.64
phenotype
0.62
microRNA
0.53
molecular function
0.53


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.32   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 452   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.32   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 452   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (42)
SERPINF1
Tbio
Novelty:  0.00555849
p_int:  0.997270474
p_ni:  0.002729526
Score:  0.156
Data Source:  BioPlex,STRINGDB
TTC19
Tbio
Novelty:  0.08251578
p_int:  0.991021236
p_ni:  0.008978764
Data Source:  BioPlex
SYNE1
Tbio
Novelty:  0.00315473
p_int:  0.93162791
p_ni:  0.005691403
p_wrong:  0.062680687
Data Source:  BioPlex
GPC3
Tbio
Novelty:  0.00151823
p_int:  0.862971333
p_ni:  0.114712523
p_wrong:  0.022316144
Score:  0.15
Data Source:  BioPlex,STRINGDB
CD109
Tbio
Novelty:  0.01280272
p_int:  0.832159178
p_ni:  0.167836704
p_wrong:  0.000004118
Data Source:  BioPlex
UBR5
Tbio
Family:  Enzyme
Novelty:  0.00608732
p_int:  0.795885412
p_ni:  0.204114588
Data Source:  BioPlex
FKBP7
Tbio
Family:  Enzyme
Novelty:  0.00572565
p_int:  0.780389374
p_ni:  0.219610493
p_wrong:  1.34e-7
Data Source:  BioPlex
STC2
Tbio
Novelty:  0.00965684
p_int:  0.754290361
p_ni:  0.245706624
p_wrong:  0.000003016
Data Source:  BioPlex
NID1
Tbio
Novelty:  0.00169075
Score:  0.935
Data Source:  Reactome,STRINGDB
LAMA3
Tbio
Novelty:  0.00733792
Score:  0.904
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Collagen degradation (R-HSA-1442490)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Collagen degradation
Reactome
Degradation of the extracellular matrix
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Collagen degradation
Degradation of the extracellular matrix
Extracellular matrix organization
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
1
1
1
30.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
1
30.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
matrix metallopeptidase 19
VGNC:5481
746523
Macaque
matrix metallopeptidase 19
710111
Mouse
MGI:1927899
58223
Rat
RGD:1311376
304608
Dog
matrix metallopeptidase 19
VGNC:43279
606853
Species
Name
OMA
EggNOG
Inparanoid
Chimp
matrix metallopeptidase 19
Macaque
matrix metallopeptidase 19
Mouse
Rat
Dog
matrix metallopeptidase 19
Publication Statistics
PubMed Score 91.32
PubMed score by year
PubTator Score 70.38
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title