You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
MMP14
Matrix metalloproteinase-14

Protein Summary
Description
Endopeptidase that degrades various components of the extracellular matrix such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development (By similarity). May be involved in actin cytoskeleton reorganization by cleaving PTK7 (PubMed:20837484). Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro-MMP2 (PubMed:12714657). Cleaves ADGRB1 to release vasculostatin-40 which inhibits angiogenesis (PubMed:22330140). Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311852
  • ENSP00000308208
  • ENSG00000157227

Symbol
  • MMP-14
  • MMP-X1
  • MT-MMP
  • MT1MMP
  • MTMMP1
  • WNCHRS
  • MT1-MMP
  • MT-MMP 1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
PubMedID
0.95
biological process
0.94
molecular function
0.9
disease perturbation
0.87


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1320.83   (req: < 5)
Gene RIFs: 430   (req: <= 3)
Antibodies: 974   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1320.83   (req: >= 5)
Gene RIFs: 430   (req: > 3)
Antibodies: 974   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 43
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 359
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (206)
GSTCD
Tbio
Family:  Enzyme
Novelty:  0.11613228
p_int:  0.999999318
p_ni:  4.05e-7
p_wrong:  2.78e-7
Data Source:  BioPlex
TMEM120B
Tdark
Novelty:  1.46242586
p_int:  0.999662208
p_ni:  0.000333009
p_wrong:  0.000004783
Data Source:  BioPlex
SERPINB5
Tbio
Novelty:  0.00192585
p_int:  0.997872658
p_ni:  0.002127342
Data Source:  BioPlex
TIMP3
Tbio
Family:  Enzyme
Novelty:  0.00134742
p_int:  0.997223079
p_ni:  0.002776914
p_wrong:  7e-9
Score:  0.886
Data Source:  BioPlex,STRINGDB
C8A
Tbio
Novelty:  0.00429321
p_int:  0.983676656
p_ni:  0.016323258
p_wrong:  8.6e-8
Data Source:  BioPlex
LRRC15
Tbio
Novelty:  0.03701624
p_int:  0.959176942
p_ni:  0.040823058
Score:  0.198
Data Source:  BioPlex,STRINGDB
RSPRY1
Tdark
Novelty:  0.26883105
p_int:  0.853599541
p_ni:  0.146365363
p_wrong:  0.000035096
Data Source:  BioPlex
POF1B
Tbio
Novelty:  0.1232792
p_int:  0.840328191
p_ni:  0.159671809
Data Source:  BioPlex
TIMP2
Tbio
Family:  Enzyme
Novelty:  0.00064016
p_int:  0.777079153
p_ni:  0.222920847
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
TIMP1
Tbio
Family:  Enzyme
Novelty:  0.00020986
Score:  0.98
Data Source:  STRINGDB
Pathways (765)
Activation of Matrix Metalloproteinases (R-HSA-1592389)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of Matrix Metalloproteinases
Reactome
Collagen degradation
Reactome
Degradation of the extracellular matrix
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Activation of Matrix Metalloproteinases
Collagen degradation
Degradation of the extracellular matrix
Extracellular matrix organization
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (55)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
4
4
3
5.7
91
mathematical ability
3
2
3
84.7
heel bone mineral density
3
1
3
81.2
cup-to-disc ratio measurement
2
2
2
78.7
Dupuytren Contracture
1
1
0
1.3
71.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
3
5.7
91
mathematical ability
3
84.7
heel bone mineral density
3
81.2
cup-to-disc ratio measurement
2
78.7
Dupuytren Contracture
0
1.3
71.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
matrix metallopeptidase 14
VGNC:7448
742887
Macaque
matrix metallopeptidase 14
712429
Mouse
MGI:101900
17387
Rat
RGD:620198
81707
Dog
matrix metallopeptidase 14
VGNC:43277
403823
Species
Name
OMA
EggNOG
Inparanoid
Chimp
matrix metallopeptidase 14
Macaque
matrix metallopeptidase 14
Mouse
Rat
Dog
matrix metallopeptidase 14
Publication Statistics
PubMed Score 1320.83
PubMed score by year
PubTator Score 1160.53
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title