Protein Summary
Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CTGF. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CTGF. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion. This gene encodes a member of the peptidase M10 family of matrix ...more
- ENST00000260302
- ENSP00000260302
- ENSG00000137745
- CLG3
- MDST
- MANDP1
- MMP-13
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
protein domain | 1 | ||
biological term | 0.98 | ||
gene perturbation | 0.85 | ||
chemical | 0.82 | ||
disease | 0.76 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1748.44 (req: < 5)
Gene RIFs: 259 (req: <= 3)
Antibodies: 971 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1748.44 (req: >= 5)
Gene RIFs: 259 (req: > 3)
Antibodies: 971 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 2170
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (2170)
Protein-Protein Interactions (199)
MYCBP2
Family: Enzyme
Novelty: 0.00413684
p_int: 0.999985544
p_ni: 0.000014456
Data Source: BioPlex
FBXO45
Novelty: 0.05784607
p_int: 0.999706516
p_ni: 0.000283778
p_wrong: 0.000009706
Data Source: BioPlex
PEAK1
Family: Kinase
Novelty: 0.02919858
p_int: 0.997177393
p_ni: 0.002822606
p_wrong: 1e-9
Data Source: BioPlex
SPRYD3
Novelty: 3.99875244
p_int: 0.991992985
p_ni: 0.000021102
p_wrong: 0.007985913
Data Source: BioPlex
HTRA2
Family: Enzyme
Novelty: 0.00343249
p_int: 0.991298641
p_ni: 0.008701359
Data Source: BioPlex
ADAMTS2
Family: Enzyme
Novelty: 0.00852208
p_int: 0.945194648
p_ni: 0.054542912
p_wrong: 0.00026244
Score: 0.362
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (68)
Reactome (11)
KEGG (3)
PathwayCommons (3)
WikiPathways (51)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Activation of Matrix Metalloproteinases | ||||
Reactome | Assembly of collagen fibrils and other multimeric structures | ||||
Reactome | Collagen degradation | ||||
Reactome | Collagen formation | ||||
Reactome | Degradation of the extracellular matrix | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Activation of Matrix Metalloproteinases | ||||
Assembly of collagen fibrils and other multimeric structures | ||||
Collagen degradation | ||||
Collagen formation | ||||
Degradation of the extracellular matrix | ||||
Viral Interactions (0)
Gene Ontology Terms (16)
Functions (5)
Components (3)
Processes (8)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Traceable Author Statement (TAS) | Reactome | |||
Disease Associations (null)
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
matrix metalloproteinase 12 measurement | 1 | 4 | 4 | 98.2 | |||||
matrix metalloproteinase measurement | 1 | 2 | 2 | 89.7 | |||||
blood protein measurement | 1 | 1 | 1 | 87.9 | |||||
emphysema pattern measurement | 1 | 2 | 3 | 45.6 | |||||
matrix metalloproteinase 1 measurement | 1 | 1 | 1 | 32.7 | |||||
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
matrix metalloproteinase 12 measurement | 4 | 98.2 | |||||
matrix metalloproteinase measurement | 2 | 89.7 | |||||
blood protein measurement | 1 | 87.9 | |||||
emphysema pattern measurement | 3 | 45.6 | |||||
matrix metalloproteinase 1 measurement | 1 | 32.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | matrix metallopeptidase 13 | VGNC:1095 | 451513 | |||||
Macaque | matrix metallopeptidase 13 | 703980 | ||||||
Mouse | MGI:1340026 | 17386 | ||||||
Rat | RGD:620196 | 171052 | ||||||
Dog | matrix metallopeptidase 13 | VGNC:43276 | 403763 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | matrix metallopeptidase 13 | |||||
Macaque | matrix metallopeptidase 13 | |||||
Mouse | ||||||
Rat | ||||||
Dog | matrix metallopeptidase 13 | |||||
Publication Statistics
PubMed Score 1748.44
PubMed score by year
PubTator Score 1057.39
PubTator score by year
Related Publications
Text Mined References (303)
GeneRif Annotations (259)
Items per page:
0 of 0
PMID | Year | Title |
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