Protein Summary
Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X (PubMed:2557822, PubMed:2153297, PubMed:1645757). In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity (PubMed:16807369). This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down the interstitial collagens, including types I, II, and III. The gene is part of a cluster of MMP genes on chromosome 11. Mutations in this gene are associated with chronic obstructive pulmonary disease (COP ...more
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3232.19 (req: < 5)
Gene RIFs: 727 (req: <= 3)
Antibodies: 1051 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3232.19 (req: >= 5)
Gene RIFs: 727 (req: > 3)
Antibodies: 1051 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 1462
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (1462)
Protein-Protein Interactions (203)
Nearest Tclin Targets (3)
Upstream (3)
1 – 3 of 3
Pathways (44)
Reactome (13)
KEGG (6)
PathwayCommons (7)
WikiPathways (18)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activation of Matrix Metalloproteinases | ||||
Reactome | Basigin interactions | ||||
Reactome | Cell surface interactions at the vascular wall | ||||
Reactome | Collagen degradation | ||||
Reactome | Cytokine Signaling in Immune system | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activation of Matrix Metalloproteinases | ||||
Basigin interactions | ||||
Cell surface interactions at the vascular wall | ||||
Collagen degradation | ||||
Cytokine Signaling in Immune system | ||||
Viral Interactions (0)
Gene Ontology Terms (14)
Functions (4)
Components (2)
Processes (8)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | ParkinsonsUK-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations ()
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
matrix metalloproteinase 1 measurement | 2 | 3 | 3 | 98.1 | |||||
blood protein measurement | 1 | 3 | 3 | 97.8 | |||||
matrix metalloproteinase measurement | 1 | 3 | 3 | 96.7 | |||||
matrix metalloproteinase 10 measurement | 1 | 1 | 1 | 49.5 | |||||
matrix metalloproteinase 12 measurement | 1 | 1 | 1 | 46 | |||||
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
matrix metalloproteinase 1 measurement | 3 | 98.1 | |||||
blood protein measurement | 3 | 97.8 | |||||
matrix metalloproteinase measurement | 3 | 96.7 | |||||
matrix metalloproteinase 10 measurement | 1 | 49.5 | |||||
matrix metalloproteinase 12 measurement | 1 | 46 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | matrix metallopeptidase 1 | VGNC:1097 | 451510 | |||||
Macaque | matrix metallopeptidase 1 | 703653 | ||||||
Mouse | MGI:1933847 | 83996 | ||||||
Rat | RGD:1307917 | 300339 | ||||||
Dog | matrix metallopeptidase 1 | VGNC:43273 | 489428 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | matrix metallopeptidase 1 | |||||
Macaque | matrix metallopeptidase 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | matrix metallopeptidase 1 | |||||
Publication Statistics
PubMed Score 3232.19
PubMed score by year
PubTator Score 3100.92
PubTator score by year
Related Publications
Text Mined References (881)
GeneRif Annotations (727)
Items per page:
0 of 0
PMID | Year | Title |
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