Protein Summary
Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids (PubMed:15283675, PubMed:8168535). Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond (PubMed:17101991). Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 (PubMed:15283675). Involved in the degradation of atrial natriuretic factor (ANF) (PubMed:2531377, PubMed:2972276). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers (PubMed:20876573). The protein encoded by this gene is a type II transmembrane glycoprotein and a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). The encoded protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. The pr ...more
- ENST00000360490
- ENSP00000353679
- ENSG00000196549
- ENST00000460393
- ENSP00000418525
- ENST00000462745
- ENSP00000419653
- ENST00000492661
- ENSP00000420389
- ENST00000493237
- ENSP00000417079
- ENST00000615825
- ENSP00000478173
- EPN
- NEP
- SFE
- CD10
- CALLA
- CMT2T
- SCA43
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
PubMedID | 0.95 | ||
cellular component | 0.8 | ||
disease | 0.78 | ||
protein domain | 0.73 | ||
hub protein | 0.71 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5347.71 (req: < 5)
Gene RIFs: 237 (req: <= 3)
Antibodies: 2082 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5347.71 (req: >= 5)
Gene RIFs: 237 (req: > 3)
Antibodies: 2082 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 19
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 391
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 3
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (3)
Active Ligands (391)
Protein-Protein Interactions (261)
P10314
Novelty: 0.00270731
p_int: 0.999379371
p_ni: 0.000620629
Score: 0.364
Data Source: BioPlex,STRINGDB
GLT8D2
Family: Enzyme
Novelty: 0.79488367
p_int: 0.995822912
p_ni: 0.000605202
p_wrong: 0.003571886
Score: 0.175
Data Source: BioPlex,STRINGDB
PXMP2
Novelty: 0.24472872
p_int: 0.990695666
p_ni: 0.009304332
p_wrong: 2e-9
Data Source: BioPlex
POMGNT1
Family: Enzyme
Novelty: 0.00755927
p_int: 0.981334051
p_ni: 0.018665949
Score: 0.185
Data Source: BioPlex,STRINGDB
SLC10A7
Family: Transporter
Novelty: 0.15556211
p_int: 0.979076437
p_ni: 0.020015103
p_wrong: 0.00090846
Data Source: BioPlex
STARD3
Novelty: 0.01540936
p_int: 0.976399229
p_ni: 0.023600544
p_wrong: 2.27e-7
Score: 0.152
Data Source: BioPlex,STRINGDB
MANEAL
Family: Enzyme
Novelty: 0.71535497
p_int: 0.96881441
p_ni: 0.03118559
Data Source: BioPlex
TENM3
Novelty: 0.0251948
p_int: 0.968742657
p_ni: 0.030880987
p_wrong: 0.000376356
Score: 0.182
Data Source: BioPlex,STRINGDB
TMEM223
Novelty: 0.89146194
p_int: 0.949647882
p_ni: 0.050341454
p_wrong: 0.000010663
Data Source: BioPlex
Nearest Tclin Targets
Pathways (12)
Reactome (6)
KEGG (4)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Reactome | Metabolism of Angiotensinogen to Angiotensins | ||||
Reactome | Metabolism of proteins | ||||
Reactome | Neutrophil degranulation | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Immune System | ||||
Innate Immune System | ||||
Metabolism of Angiotensinogen to Angiotensins | ||||
Metabolism of proteins | ||||
Neutrophil degranulation | ||||
Viral Interactions (0)
Gene Ontology Terms (32)
Functions (6)
Components (13)
Processes (13)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Experiment (EXP) | Reactome | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Disease Associations ()
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
testosterone measurement | 2 | 1 | 2 | 50.6 | |||||
diastolic blood pressure | 1 | 1 | 1 | 12.8 | |||||
hemoglobin measurement | 1 | 1 | 1 | 5.8 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
testosterone measurement | 2 | 50.6 | |||||
diastolic blood pressure | 1 | 12.8 | |||||
hemoglobin measurement | 1 | 5.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | membrane metalloendopeptidase | VGNC:14231 | 460792 | |||||
Macaque | membrane metalloendopeptidase | 707667 | ||||||
Mouse | MGI:97004 | 17380 | ||||||
Rat | RGD:3098 | 24590 | ||||||
Dog | membrane metalloendopeptidase | VGNC:43271 | 477120 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | membrane metalloendopeptidase | |||||
Macaque | membrane metalloendopeptidase | |||||
Mouse | ||||||
Rat | ||||||
Dog | membrane metalloendopeptidase | |||||
Publication Statistics
PubMed Score 5347.71
PubMed score by year
PubTator Score 2796.30
PubTator score by year
Related Publications
Text Mined References (283)
GeneRif Annotations (237)
Items per page:
0 of 0
PMID | Year | Title |
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