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Tbio
MLXIPL
Carbohydrate-responsive element-binding protein

Protein Summary
Description
Transcriptional repressor. Binds to the canonical and non-canonical E box sequences 5'-CACGTG-3' (By similarity). This gene encodes a basic helix-loop-helix leucine zipper transcription factor of the Myc/Max/Mad superfamily. This protein forms a heterodimeric complex and binds and activates, in a glucose-dependent manner, carbohydrate response element (ChoRE) motifs in the promoters of triglyceride synthesis genes. The gene is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313375
  • ENSP00000320886
  • ENSG00000009950
  • ENST00000345114
  • ENSP00000343767
  • ENST00000354613
  • ENSP00000346629
  • ENST00000414749
  • ENSP00000412330
  • ENST00000429400
  • ENSP00000406296

Symbol
  • BHLHD14
  • MIO
  • WBSCR14
  • MIO
  • MLX
  • CHREBP
  • MONDOB
  • WBSCR14
  • WS-bHLH
  • bHLHd14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.97
trait
0.75
disease
0.66
gene perturbation
0.63
molecular function
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 370.7   (req: < 5)
Gene RIFs: 85   (req: <= 3)
Antibodies: 315   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 370.7   (req: >= 5)
Gene RIFs: 85   (req: > 3)
Antibodies: 315   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0