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Tbio
MLST8
Target of rapamycin complex subunit LST8

Protein Summary
Description
Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, LST8 interacts directly with MTOR and enhances its kinase activity. In ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000382450
  • ENSP00000371888
  • ENSG00000167965
  • ENST00000397124
  • ENSP00000380313
  • ENST00000564088
  • ENSP00000457870
  • ENST00000565250
  • ENSP00000455046
  • ENST00000569417
  • ENSP00000456405

Symbol
  • GBL
  • LST8
  • GBL
  • LST8
  • POP3
  • WAT1
  • GbetaL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.85
protein domain
0.85
pathway
0.76
transcription factor
0.69
transcription factor binding site profile
0.69


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 210.98   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 447   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 210.98   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 447   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (177)
MTOR
Tclin
Family:  Kinase
Novelty:  0.00012333
p_int:  0.999999343
p_ni:  6.57e-7
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
LYPLA2
Tchem
Family:  Enzyme
Novelty:  0.05436006
p_int:  0.999640596
p_ni:  0.000273974
p_wrong:  0.00008543
Score:  0.22
Data Source:  BioPlex,STRINGDB
PRAME
Tbio
Novelty:  0.00543263
p_int:  0.997732474
p_ni:  0.002267372
p_wrong:  1.54e-7
Score:  0.183
Data Source:  BioPlex,STRINGDB
CCT7
Tbio
Novelty:  0.02247038
p_int:  0.944605828
p_ni:  0.055394172
Score:  0.219
Data Source:  BioPlex,STRINGDB
ACAT2
Tchem
Family:  Enzyme
Novelty:  0.01464168
p_int:  0.89766563
p_ni:  0.10233437
Score:  0.359
Data Source:  BioPlex,STRINGDB
FOXF2
Tbio
Family:  TF
Novelty:  0.02032168
p_int:  0.883001289
p_ni:  0.000745001
p_wrong:  0.11625371
Score:  0.183
Data Source:  BioPlex,STRINGDB
CCT2
Tbio
Novelty:  0.01967139
p_int:  0.869009699
p_ni:  0.130990301
Score:  0.201
Data Source:  BioPlex,STRINGDB
TUBA4A
Tchem
Novelty:  0.00820546
p_int:  0.866025407
p_ni:  0.133974593
Data Source:  BioPlex
CYB5B
Tbio
Novelty:  0.09395308
p_int:  0.859503285
p_ni:  0.1404965
p_wrong:  2.15e-7
Data Source:  BioPlex
CCT3
Tbio
Novelty:  0.01642521
p_int:  0.859076771
p_ni:  0.140923229
Score:  0.194
Data Source:  BioPlex,STRINGDB
Pathways (62)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 35
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Autophagy
Reactome
CD28 co-stimulation
Reactome
CD28 dependent PI3K/Akt signaling
Reactome
Cellular response to heat stress
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Autophagy
CD28 co-stimulation
CD28 dependent PI3K/Akt signaling
Cellular response to heat stress
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
2
2
1
6
91
appendicular lean mass
4
2
4
91
serum gamma-glutamyl transferase measurement
2
2
2
90.8
BMI-adjusted waist circumference
2
4
5
81.1
BMI-adjusted hip circumference
2
5
7
75.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
1
6
91
appendicular lean mass
4
91
serum gamma-glutamyl transferase measurement
2
90.8
BMI-adjusted waist circumference
5
81.1
BMI-adjusted hip circumference
7
75.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
MTOR associated protein, LST8 homolog
VGNC:5837
453830
Macaque
MTOR associated protein, LST8 homolog
695650
Mouse
MGI:1929514
56716
Rat
RGD:69242
64226
Dog
MTOR associated protein, LST8 homolog
VGNC:43266
610936
Species
Name
OMA
EggNOG
Inparanoid
Chimp
MTOR associated protein, LST8 homolog
Macaque
MTOR associated protein, LST8 homolog
Mouse
Rat
Dog
MTOR associated protein, LST8 homolog
Publication Statistics
PubMed Score 210.98
PubMed score by year
PubTator Score 50.59
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title