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Tdark
MLLT6
Protein AF-17

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000618876
  • ENSP00000477969
  • ENSG00000275851
  • ENST00000621332
  • ENSP00000479910
  • ENSG00000275023

Symbol
  • AF17
  • AF17
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.88
transcription factor
0.86
virus perturbation
0.76
PubMedID
0.75
protein domain
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.45   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.45   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (86)
MLLT10
Tbio
Family:  Epigenetic
Novelty:  0.00590548
p_int:  0.999999987
p_ni:  1.1e-8
p_wrong:  1e-9
Score:  0.343
Data Source:  BioPlex,STRINGDB
DOT1L
Tchem
Family:  Epigenetic
Novelty:  0.00361358
p_int:  0.999999855
p_ni:  1.45e-7
Score:  0.849
Data Source:  BioPlex,STRINGDB
GULP1
Tbio
Novelty:  0.01367525
p_int:  0.999999666
p_ni:  3.34e-7
Score:  0.189
Data Source:  BioPlex,STRINGDB
ZC3H10
Tbio
Novelty:  0.22647282
p_int:  0.999989573
p_ni:  0.000010425
p_wrong:  2e-9
Score:  0.189
Data Source:  BioPlex,STRINGDB
CREB5
Tbio
Family:  TF
Novelty:  0.03857106
p_int:  0.999972508
p_ni:  0.000027492
Score:  0.713
Data Source:  BioPlex,STRINGDB
MID1
Tbio
Family:  Enzyme
Novelty:  0.02400169
p_int:  0.999918549
p_ni:  0.000081444
p_wrong:  7e-9
Score:  0.164
Data Source:  BioPlex,STRINGDB
EEA1
Tbio
Novelty:  0.00242832
p_int:  0.999881541
p_ni:  0.000118459
Score:  0.158
Data Source:  BioPlex,STRINGDB
MLLT3
Tchem
Novelty:  0.00361056
p_int:  0.999836249
p_ni:  0.000163751
Score:  0.86
Data Source:  BioPlex,STRINGDB
ATF7
Tbio
Family:  TF
Novelty:  0.01470313
p_int:  0.999778757
p_ni:  0.000221243
Score:  0.677
Data Source:  BioPlex,STRINGDB
DAXX
Tbio
Novelty:  0.00348585
p_int:  0.998640558
p_ni:  0.000001477
p_wrong:  0.001357965
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (16)
Items per page:
1 – 5 of 16
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
1
1
1
78.4
FEV/FEC ratio
1
1
1
78.4
body height
2
1
2
68
body height
2
1
2
68
heel bone mineral density
2
1
2
52.4
Items per page:
1 – 5 of 16
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
1
78.4
FEV/FEC ratio
1
78.4
body height
2
68
body height
2
68
heel bone mineral density
2
52.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
MLLT6, PHD finger containing
VGNC:12460
454612
Macaque
MLLT6, PHD finger containing
694045
Mouse
MGI:1935145
246198
Rat
RGD:1306689
303504
Dog
MLLT6, PHD finger containing
VGNC:43263
608565
Species
Name
OMA
EggNOG
Inparanoid
Chimp
MLLT6, PHD finger containing
Macaque
MLLT6, PHD finger containing
Mouse
Rat
Dog
MLLT6, PHD finger containing
Publication Statistics
PubMed Score 24.45
PubMed score by year
PubTator Score 12.95
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title