Tchem MLLT3 Protein AF-9

Protein Summary

Description

Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA (PubMed:20159561, PubMed:20471948, PubMed:25417107, PubMed:27105114, PubMed:27545619). Specifically recognizes and binds acylated histone H3, with a marked preference for histone H3 that is crotonylated (PubMed:25417107, PubMed:27105114, PubMed:27545619). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:25417107, PubMed:27105114, PubMed:27545619). Recognizes and binds histone H3 crotonylated at 'Lys-9' (H3K9cr), and with slightly lower affinity histone H3 crotonylated at 'Lys-18' (H3K18cr) (PubMed:27105114). Also recognizes and binds histone H3 acetylated at 'Lys-9' (H3K9ac), but with lower affinity than crotonylated histone H3 (PubMed:25417107, PubMed:27105114). In the SEC complex, MLLT3 is required to recruit the complex to crotonylated histones (PubMed:27105114, PubMed:27545619).

Uniprot Accession IDs

• P42568
• B1AMQ2
• B2R7B3
• B7Z755
• D3DRJ8
• Q8IVB0

Gene Name

• MLLT3

Ensembl ID

• ENST00000380338
• ENSP00000369695
• ENSG00000171843
• ENST00000630269
• ENSP00000485996

Symbol

• AF9
• YEATS3
• AF9
• YEATS3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.98
PubMedID	0.93
virus perturbation	0.85
transcription factor binding site profile	0.79
histone modification site profile	0.72

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Protein Af-9

Protein / Nucleic Acid Binding / Dna Binding Protein / Chromatin/chromatin-binding Protein / Protein Af-9

DTO Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Chromatin/chromatin-binding Protein / Protein Af-9

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 284.65   (req: < 5)

Gene RIFs: 33   (req: <= 3)

Antibodies: 261   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 284.65   (req: >= 5)

Gene RIFs: 33   (req: > 3)

Antibodies: 261   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 22

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (22)

Explore Active Ligands

1 – 10 of 22

CHEMBL4206834

MLLT3Tchem

pKi : 6.92

CHEMBL4204744

MLLT3Tchem

pKi : 7.2

CHEMBL4211204

MLLT3Tchem

pKi : 7

CHEMBL4209820

MLLT3Tchem

pKi : 6.82

CHEMBL4216416

MLLT3Tchem

pKi : 7.05

CHEMBL4211714

MLLT3Tchem

pKi : 7.25

CHEMBL4216933

MLLT3Tchem

pKi : 6.43

CHEMBL4211962

MLLT3Tchem

pKi : 6.38

CHEMBL4216170

MLLT3Tchem

pKi : 6.54

CHEMBL4209508

MLLT3Tchem

pKi : 6.29

Protein-Protein Interactions (233)

Explore Interacting Targets

1 – 10 of 233

• See Interactions on String-DB

PIP4K2A

Tbio

Family:  Kinase

Novelty:  0.01130885

p_int:  0.999999679

p_ni:  3.21e-7

Score:  0.184

Data Source:  BioPlex,STRINGDB

EPB41L1

Tbio

Novelty:  0.02937451

p_int:  0.999999353

p_ni:  6.47e-7

Data Source:  BioPlex

EPB41L3

Tbio

Novelty:  0.00915217

p_int:  0.999996778

p_ni:  0.000003222

Data Source:  BioPlex

EPB41L2

Tbio

Novelty:  0.0311733

p_int:  0.999996319

p_ni:  0.000003681

Data Source:  BioPlex

CAMKV

Tbio

Family:  Kinase

Novelty:  0.17794181

p_int:  0.999995742

p_ni:  0.000004258

Data Source:  BioPlex

ELL3

Tbio

Family:  Enzyme

Novelty:  0.18245631

p_int:  0.999984043

p_ni:  0.000015957

Score:  0.812

Data Source:  BioPlex,STRINGDB

MLLT6

Tdark

Family:  Epigenetic

Novelty:  0.03728427

p_int:  0.999836249

p_ni:  0.000163751

Score:  0.86

Data Source:  BioPlex,STRINGDB

SNX24

Tdark

Novelty:  0.20838126

p_int:  0.999342684

p_ni:  0.000657306

p_wrong:  1e-8

Data Source:  BioPlex

BPIFB1

Tbio

Novelty:  0.03980683

p_int:  0.999230328

p_ni:  0.000769669

p_wrong:  3e-9

Score:  0.183

Data Source:  BioPlex,STRINGDB

MDK

Tchem

Novelty:  0.00145301

p_int:  0.999063395

p_ni:  0.000936605

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (6)

Reactome (5)

KEGG (1)

Formation of RNA Pol II elongation complex (R-HSA-112382)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Formation of RNA Pol II elongation complex	61 targets	R-HSA-112382
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	RNA Polymerase II Pre-transcription Events	84 targets	R-HSA-674695
Reactome	RNA Polymerase II Transcription	1314 targets	R-HSA-73857
Reactome	RNA Polymerase II Transcription Elongation	61 targets	R-HSA-75955

Name	Explore in Pharos	Explore in Source
Formation of RNA Pol II elongation complex	61 targets	R-HSA-112382
Gene expression (Transcription)	1452 targets	R-HSA-74160
RNA Polymerase II Pre-transcription Events	84 targets	R-HSA-674695
RNA Polymerase II Transcription	1314 targets	R-HSA-73857
RNA Polymerase II Transcription Elongation	61 targets	R-HSA-75955

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (17)

Functions (5)

Components (5)

Processes (7)

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1 – 5 of 5

GO Term	Evidence	Assigned by
chromatin binding	Inferred from Direct Assay (IDA)	UniProtKB
histone binding	Inferred from Direct Assay (IDA)	UniProtKB
lysine-acetylated histone binding	Inferred from Direct Assay (IDA)	UniProtKB
modification-dependent protein binding	Inferred from Direct Assay (IDA)	UniProtKB
DNA-binding transcription factor activity, RNA polymerase II-specific	Inferred from Sequence Model (ISM)	NTNU_SB

Disease Associations ()

No disease associations found

GWAS Traits (8)

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1 – 5 of 8

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
glomerular filtration rate	EFO_0005208	2	2	2		70.4
smoking status measurement	EFO_0006527	2	1	2		46.5
hemoglobin measurement	EFO_0004509	2	1	2		42.3
hematocrit	EFO_0004348	2	1	2		39.6
mean reticulocyte volume	EFO_0010701	1	1	1		35

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 8

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
glomerular filtration rate	EFO_0005208	2		70.4
smoking status measurement	EFO_0006527	2		46.5
hemoglobin measurement	EFO_0004509	2		42.3
hematocrit	EFO_0004348	2		39.6
mean reticulocyte volume	EFO_0010701	1		35

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Activator
Alternative splicing
Chromosomal rearrangement
Chromosome
Complete proteome
Isopeptide bond
Nucleus
Phosphoprotein
Proto-oncogene

GWAS Trait Find Similar Targets

No Header	No Header
FEV change measurement
glomerular filtration rate
hematocrit
hemoglobin measurement
mean reticulocyte volume
response to montelukast
smoking status measurement
urate measurement

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
embryo phenotype
growth/size/body region phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
mortality/aging
skeleton phenotype

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	MLLT3, super elongation complex subunit	VGNC:13917	744085
Macaque	MLLT3, super elongation complex subunit		711732
Mouse	myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3	MGI:1917372	70122
Rat	MLLT3, super elongation complex subunit	RGD:620940	114510
Dog	MLLT3, super elongation complex subunit	VGNC:43262	481556

Species	Name	OMA	EggNOG	Inparanoid
Chimp	MLLT3, super elongation complex subunit
Macaque	MLLT3, super elongation complex subunit
Mouse	myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3
Rat	MLLT3, super elongation complex subunit
Dog	MLLT3, super elongation complex subunit

Publication Statistics

PubMed Score 284.65

PubMed score by year

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PubTator Score 113.55

PubTator score by year

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Related Publications

Text Mined References (53)

GeneRif Annotations (33)

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PMID	Year	Title