Protein Summary
Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA (PubMed:20159561, PubMed:20471948, PubMed:25417107, PubMed:27105114, PubMed:27545619). Specifically recognizes and binds acylated histone H3, with a marked preference for histone H3 that is crotonylated (PubMed:25417107, PubMed:27105114, PubMed:27545619). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:25417107, PubMed:27105114, PubMed:27545619). Recognizes and binds histone H3 crotonylated at 'Lys-9' (H3K9cr), and with slightly lower affinity histone H3 crotonylated at 'Lys-18' (H3K18cr) (PubMed:27105114). Also recognizes and binds histone H3 acetylated at 'Lys-9' (H3K9ac), but with lower affinity than crotonylated histone H3 (PubMed:25417107, PubMed:27105114). In the SEC complex, MLLT3 is re ...more
- ENST00000380338
- ENSP00000369695
- ENSG00000171843
- ENST00000630269
- ENSP00000485996
- AF9
- YEATS3
- AF9
- YEATS3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
transcription factor perturbation | 0.98 | ||
PubMedID | 0.93 | ||
virus perturbation | 0.85 | ||
transcription factor binding site profile | 0.79 | ||
histone modification site profile | 0.72 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 284.65 (req: < 5)
Gene RIFs: 33 (req: <= 3)
Antibodies: 261 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 284.65 (req: >= 5)
Gene RIFs: 33 (req: > 3)
Antibodies: 261 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 22
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (22)
Protein-Protein Interactions (233)
PIP4K2A
Family: Kinase
Novelty: 0.01130885
p_int: 0.999999679
p_ni: 3.21e-7
Score: 0.184
Data Source: BioPlex,STRINGDB
CAMKV
Family: Kinase
Novelty: 0.17794181
p_int: 0.999995742
p_ni: 0.000004258
Data Source: BioPlex
ELL3
Family: Enzyme
Novelty: 0.18245631
p_int: 0.999984043
p_ni: 0.000015957
Score: 0.812
Data Source: BioPlex,STRINGDB
MLLT6
Family: Epigenetic
Novelty: 0.03728427
p_int: 0.999836249
p_ni: 0.000163751
Score: 0.86
Data Source: BioPlex,STRINGDB
SNX24
Novelty: 0.20838126
p_int: 0.999342684
p_ni: 0.000657306
p_wrong: 1e-8
Data Source: BioPlex
BPIFB1
Novelty: 0.03980683
p_int: 0.999230328
p_ni: 0.000769669
p_wrong: 3e-9
Score: 0.183
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (6)
Reactome (5)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Formation of RNA Pol II elongation complex | ||||
Reactome | Gene expression (Transcription) | ||||
Reactome | RNA Polymerase II Pre-transcription Events | ||||
Reactome | RNA Polymerase II Transcription | ||||
Reactome | RNA Polymerase II Transcription Elongation | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Formation of RNA Pol II elongation complex | ||||
Gene expression (Transcription) | ||||
RNA Polymerase II Pre-transcription Events | ||||
RNA Polymerase II Transcription | ||||
RNA Polymerase II Transcription Elongation | ||||
Viral Interactions (0)
Gene Ontology Terms (17)
Functions (5)
Components (5)
Processes (7)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Sequence Model (ISM) | NTNU_SB | |||
Disease Associations ()
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
glomerular filtration rate | 2 | 2 | 2 | 70.4 | |||||
smoking status measurement | 2 | 1 | 2 | 46.5 | |||||
hemoglobin measurement | 2 | 1 | 2 | 42.3 | |||||
hematocrit | 2 | 1 | 2 | 39.6 | |||||
mean reticulocyte volume | 1 | 1 | 1 | 35 | |||||
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
glomerular filtration rate | 2 | 70.4 | |||||
smoking status measurement | 2 | 46.5 | |||||
hemoglobin measurement | 2 | 42.3 | |||||
hematocrit | 2 | 39.6 | |||||
mean reticulocyte volume | 1 | 35 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | MLLT3, super elongation complex subunit | VGNC:13917 | 744085 | |||||
Macaque | MLLT3, super elongation complex subunit | 711732 | ||||||
Mouse | MGI:1917372 | 70122 | ||||||
Rat | RGD:620940 | 114510 | ||||||
Dog | MLLT3, super elongation complex subunit | VGNC:43262 | 481556 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | MLLT3, super elongation complex subunit | |||||
Macaque | MLLT3, super elongation complex subunit | |||||
Mouse | ||||||
Rat | ||||||
Dog | MLLT3, super elongation complex subunit | |||||
Publication Statistics
PubMed Score 284.65
PubMed score by year
PubTator Score 113.55
PubTator score by year
Related Publications
Text Mined References (53)
GeneRif Annotations (33)
Items per page:
0 of 0
PMID | Year | Title |
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