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Tbio
MLF1
Myeloid leukemia factor 1

Protein Summary
Description
Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus. This gene encodes an oncoprotein which is thought to play a role in the phenotypic determination of hemopoetic cells. Translocations between this gene and nucleophosmin have been associated with myelodysplastic syndrome and acute myeloid leukemia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355893
  • ENSP00000348157
  • ENSG00000178053
  • ENST00000359117
  • ENSP00000352025
  • ENST00000392822
  • ENSP00000376568
  • ENST00000469452
  • ENSP00000418595
  • ENST00000471745
  • ENSP00000420134
  • ENST00000478894
  • ENSP00000417777
  • ENST00000482628
  • ENSP00000417141
  • ENST00000484955
  • ENSP00000417835
  • ENST00000618075
  • ENSP00000484169
  • ENST00000619577
  • ENSP00000483337
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.8
transcription factor perturbation
0.8
disease perturbation
0.79
gene perturbation
0.68
tissue sample
0.67


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.21   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 472   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.21   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 472   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (102)
SYNRG
Tdark
Novelty:  0.03621564
p_int:  0.999992222
p_ni:  0.000007776
p_wrong:  2e-9
Data Source:  BioPlex
CRYBG3
Tdark
Family:  Enzyme
Novelty:  0.24063491
p_int:  0.999948467
p_ni:  0.000051463
p_wrong:  7e-8
Score:  0.177
Data Source:  BioPlex,STRINGDB
TRO
Tbio
Novelty:  0.02850833
p_int:  0.999383945
p_ni:  0.000616055
Data Source:  BioPlex
CEP295
Tbio
Novelty:  0.22993687
p_int:  0.999244618
p_ni:  0.000010052
p_wrong:  0.00074533
Score:  0.537
Data Source:  BioPlex,STRINGDB
BRCA2
Tbio
Novelty:  0.0002217
p_int:  0.998314682
p_ni:  0.001685318
Score:  0.211
Data Source:  BioPlex,STRINGDB
OTUD3
Tbio
Novelty:  0.11839931
p_int:  0.99794053
p_ni:  0.002059469
p_wrong:  1e-9
Data Source:  BioPlex
ERCC6L
Tbio
Novelty:  0.01959203
p_int:  0.997869225
p_ni:  0.002130766
p_wrong:  9e-9
Data Source:  BioPlex
DNAJB8
Tbio
Novelty:  0.0791748
p_int:  0.997678939
p_ni:  0.002321061
Score:  0.226
Data Source:  BioPlex,STRINGDB
PDE4DIP
Tbio
Novelty:  0.03414104
p_int:  0.996934017
p_ni:  0.003065982
Data Source:  BioPlex
BUB1
Tchem
Family:  Kinase
Novelty:  0.00327514
p_int:  0.992235422
p_ni:  0.007764576
p_wrong:  2e-9
Score:  0.47
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vital capacity
3
3
3
96.4
forced expiratory volume
2
2
2
87.3
systolic blood pressure
2
2
2
66.5
diastolic blood pressure
2
3
3
64.6
educational attainment
1
3
3
59.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vital capacity
3
96.4
forced expiratory volume
2
87.3
systolic blood pressure
2
66.5
diastolic blood pressure
3
64.6
educational attainment
3
59.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
myeloid leukemia factor 1
460811
Macaque
myeloid leukemia factor 1
704116
Mouse
MGI:1341819
17349
Rat
RGD:1306854
310483
Dog
myeloid leukemia factor 1
477127
Species
Name
OMA
EggNOG
Inparanoid
Chimp
myeloid leukemia factor 1
Macaque
myeloid leukemia factor 1
Mouse
Rat
Dog
myeloid leukemia factor 1
Publication Statistics
PubMed Score 44.21
PubMed score by year
PubTator Score 29.12
PubTator score by year
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Related Publications
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PMID
Year
Title