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Tbio
MKRN2
Probable E3 ubiquitin-protein ligase makorin-2

Protein Summary
Description
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. This gene encodes a probable E3 ubiquitin ligase containing several zinc finger domains, that is a member of the makorin RING zinc-finger protein family. This gene overlaps the v-raf-1 murine leukemia viral oncogene homolog 1 (RAF1) gene in an antisense orientation and may have a co-regulatory function with RAF1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000170447
  • ENSP00000170447
  • ENSG00000075975
  • ENST00000411987
  • ENSP00000396340

Symbol
  • RNF62
  • RNF62
  • HSPC070
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.94
protein domain
0.85
histone modification site profile
0.69
tissue sample
0.69
disease perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.91   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 270   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.91   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 270   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (45)
CARNMT1
Tbio
Family:  Enzyme
Novelty:  0.28121779
p_int:  0.99998676
p_ni:  0.00001324
Score:  0.307
Data Source:  BioPlex,STRINGDB
PAIP1
Tbio
Novelty:  0.05922084
p_int:  0.99936405
p_ni:  0.000568425
p_wrong:  0.000067525
Score:  0.764
Data Source:  BioPlex,STRINGDB
NKAPD1
Tdark
Novelty:  1.56979675
p_int:  0.996773758
p_ni:  0.003226241
p_wrong:  1e-9
Data Source:  BioPlex
LARP4B
Tbio
Novelty:  0.11363794
p_int:  0.994959531
p_ni:  0.005039608
p_wrong:  8.6e-7
Data Source:  BioPlex
PARP12
Tchem
Family:  Enzyme
Novelty:  0.08076657
p_int:  0.988298437
p_ni:  0.011701533
p_wrong:  2.9e-8
Score:  0.395
Data Source:  BioPlex,STRINGDB
APOBEC3D
Tbio
Novelty:  0.01102619
p_int:  0.980373279
p_ni:  0.019626705
p_wrong:  1.7e-8
Data Source:  BioPlex
NXF1
Tbio
Novelty:  0.00642439
p_int:  0.95947023
p_ni:  0.035791622
p_wrong:  0.004738148
Score:  0.19
Data Source:  BioPlex,STRINGDB
CIRBP
Tbio
Novelty:  0.00439066
p_int:  0.958628967
p_ni:  0.041313778
p_wrong:  0.000057255
Data Source:  BioPlex
ZC3H18
Tdark
Novelty:  0.3515546
p_int:  0.945760044
p_ni:  0.042164018
p_wrong:  0.012075937
Score:  0.178
Data Source:  BioPlex,STRINGDB
ELAVL2
Tbio
Novelty:  0.00370708
p_int:  0.923278306
p_ni:  0.075992629
p_wrong:  0.000729065
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (1)
Find Similar Targets
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
UniProt
Protein modification; protein ubiquitination.
Name
Explore in Pharos
Explore in Source
Protein modification; protein ubiquitination.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
1
12
12
94
BMI-adjusted waist-hip ratio
1
13
13
93.6
hip circumference
1
8
8
93.4
BMI-adjusted hip circumference
1
4
4
86.1
HbA1c measurement
1
2
2
84.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
12
94
BMI-adjusted waist-hip ratio
13
93.6
hip circumference
8
93.4
BMI-adjusted hip circumference
4
86.1
HbA1c measurement
2
84.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
makorin ring finger protein 2
VGNC:2048
460180
Macaque
makorin ring finger protein 2
697649
Mouse
MGI:1914277
67027
Rat
RGD:1310618
297525
Dog
makorin ring finger protein 2
VGNC:43252
476531
Species
Name
OMA
EggNOG
Inparanoid
Chimp
makorin ring finger protein 2
Macaque
makorin ring finger protein 2
Mouse
Rat
Dog
makorin ring finger protein 2
Publication Statistics
PubMed Score 9.91
PubMed score by year
PubTator Score 3.53
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title