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Tchem
MKNK2
MAP kinase-interacting serine/threonine-protein kinase 2

Protein Summary
Description
Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Isoform 1 displays a high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal. This gene encodes a member of the calcium/calmodulin-dependent protein kinases (CAMK) Ser/Thr protein kinase family, which belongs to the protein kinase superfamily. This protein contains conserve ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000250896
  • ENSP00000250896
  • ENSG00000099875
  • ENST00000309340
  • ENSP00000309485
  • ENST00000591601
  • ENSP00000467811

Symbol
  • GPRK7
  • MNK2
  • MNK2
  • GPRK7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule
1
molecular function
0.97
transcription factor binding site profile
0.79
kinase perturbation
0.76
microRNA
0.76


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.03   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 283   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.03   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 283   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 442
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (6)
Dark Kinase Knowledgebase
Thumbnail image for Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (33)
MAPK14
Tchem
Family:  Kinase
Novelty:  0.00045138
p_int:  0.999535612
p_ni:  1e-9
p_wrong:  0.000464387
Score:  0.683
Data Source:  BioPlex,STRINGDB
MAPK1
Tchem
Family:  Kinase
Novelty:  0.00061058
Score:  0.964
Data Source:  STRINGDB
MAPK3
Tchem
Family:  Kinase
Novelty:  0.00012969
Score:  0.942
Data Source:  STRINGDB
EIF4E
Tchem
Novelty:  0.00072182
Score:  0.884
Data Source:  STRINGDB
EIF4E1B
Tdark
Novelty:  0.28023341
Score:  0.827
Data Source:  STRINGDB
EIF4E2
Tbio
Novelty:  0.0490219
Score:  0.822
Data Source:  STRINGDB
MKNK1
Tchem
Family:  Kinase
Novelty:  0.01445137
Score:  0.809
Data Source:  STRINGDB
ATF4
Tbio
Family:  TF
Novelty:  0.00253408
Score:  0.808
Data Source:  STRINGDB
SRPK1
Tchem
Family:  Kinase
Novelty:  0.01066655
Score:  0.678
Data Source:  STRINGDB
EIF4G1
Tbio
Novelty:  0.00170995
Score:  0.665
Data Source:  STRINGDB
Pathways (161)
Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
HIF-1 signaling pathway
KEGG
MAPK signaling pathway
KEGG
Insulin signaling pathway
Name
Explore in Pharos
Explore in Source
HIF-1 signaling pathway
MAPK signaling pathway
Insulin signaling pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (18)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
73.3
BMI-adjusted hip circumference
2
2
2
69.8
platelet count
2
2
2
65.9
red blood cell distribution width
2
1
2
62.1
body mass index
1
1
1
44
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
73.3
BMI-adjusted hip circumference
2
69.8
platelet count
2
65.9
red blood cell distribution width
2
62.1
body mass index
1
44
Find similar targets by:
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
MAP kinase interacting serine/threonine kinase 2
VGNC:13225
455561
Macaque
MAP kinase interacting serine/threonine kinase 2
721436
Mouse
MGI:894279
17347
Rat
RGD:1305728
299618
Dog
MAP kinase interacting serine/threonine kinase 2
VGNC:43251
612212
Species
Name
OMA
EggNOG
Inparanoid
Chimp
MAP kinase interacting serine/threonine kinase 2
Macaque
MAP kinase interacting serine/threonine kinase 2
Mouse
Rat
Dog
MAP kinase interacting serine/threonine kinase 2
Publication Statistics
PubMed Score 42.03
PubMed score by year
PubTator Score 37.42
PubTator score by year
Patents
Patents by year
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Related Publications
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0 of 0
PMID
Year
Title