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Tbio
MIXL1
Homeobox protein MIXL1

Protein Summary
Description
Transcription factor that play a central role in proper axial mesendoderm morphogenesis and endoderm formation. Required for efficient differentiation of cells from the primitive streak stage to blood, by acting early in the recruitment and/or expansion of mesodermal progenitors to the hemangioblastic and hematopoietic lineages. Also involved in the morphogenesis of the heart and the gut during embryogenesis. Acts as a negative regulator of brachyury expression (By similarity). Homeodomain proteins, such as MIXL1, are transcription factors that regulate cell fate during development (Hart et al., 2005 [PubMed 15982639]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366810
  • ENSP00000355775
  • ENSG00000185155
  • ENST00000542034
  • ENSP00000442439

Symbol
  • MIXL
  • MIX
  • MIXL
  • MILD1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
biological process
0.75
histone modification site profile
0.66
disease
0.56
cellular component
0.53


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.66   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 132   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.66   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 132   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (56)
FOXH1
Tbio
Family:  TF
Novelty:  0.00823939
Score:  0.835
Data Source:  STRINGDB
TBXT
Tbio
Family:  TF
Novelty:  0.00660122
Score:  0.806
Data Source:  STRINGDB
EOMES
Tbio
Family:  TF
Novelty:  0.00288125
Score:  0.783
Data Source:  STRINGDB
SOX17
Tbio
Family:  TF
Novelty:  0.00328146
Score:  0.769
Data Source:  STRINGDB
FOXA2
Tbio
Family:  TF
Novelty:  0.00244521
Score:  0.73
Data Source:  STRINGDB
TBX6
Tbio
Family:  TF
Novelty:  0.01060902
Score:  0.682
Data Source:  STRINGDB
FOXA1
Tbio
Family:  TF
Novelty:  0.00235269
Score:  0.68
Data Source:  STRINGDB
SOX1
Tbio
Family:  TF
Novelty:  0.0045679
Score:  0.664
Data Source:  STRINGDB
GATA4
Tbio
Family:  TF
Novelty:  0.00094282
Score:  0.663
Data Source:  STRINGDB
NANOG
Tbio
Family:  TF
Novelty:  0.00054893
Score:  0.655
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Adipogenesis
WikiPathways
Adipogenesis
WikiPathways
Mesodermal Commitment Pathway
WikiPathways
Endoderm Differentiation
WikiPathways
PDGFR-beta pathway
Name
Explore in Pharos
Explore in Source
Adipogenesis
Adipogenesis
Mesodermal Commitment Pathway
Endoderm Differentiation
PDGFR-beta pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (23)
Find Similar Targets
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence Alignment (ISA)
NTNU_SB
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
5
1
5
69.8
mean platelet volume
2
1
2
61.4
mean corpuscular hemoglobin concentration
1
1
1
56.2
neutrophil count
1
1
1
46.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
5
69.8
mean platelet volume
2
61.4
mean corpuscular hemoglobin concentration
1
56.2
neutrophil count
1
46.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Mix paired-like homeobox
737620
Macaque
Mix paired-like homeobox
699179
Mouse
MGI:1351322
27217
Rat
RGD:11496769
108348182
Horse
Mix paired-like homeobox [Source:HGNC Symbol;Acc:HGNC:13363]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Mix paired-like homeobox
Macaque
Mix paired-like homeobox
Mouse
Rat
Horse
Mix paired-like homeobox [Source:HGNC Symbol;Acc:HGNC:13363]
Publication Statistics
PubMed Score 48.66
PubMed score by year
PubTator Score 211.30
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title