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Tchem
MITF
Microphthalmia-associated transcription factor

Protein Summary
Description
Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to M-boxes (5'-TCATGTG-3') and symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium. The protein encoded by this gene is a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. The encoded protein regulates melanocyte development and is responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waard ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314557
  • ENSP00000324246
  • ENSG00000187098
  • ENST00000314589
  • ENSP00000324443
  • ENST00000328528
  • ENSP00000327867
  • ENST00000352241
  • ENSP00000295600
  • ENST00000394351
  • ENSP00000377880
  • ENST00000448226
  • ENSP00000391803
  • ENST00000472437
  • ENSP00000418845
  • ENST00000531774
  • ENSP00000435909
  • ENST00000642352
  • ENSP00000494105

Symbol
  • BHLHE32
  • MI
  • WS2
  • CMM8
  • WS2A
  • COMMAD
  • bHLHe32
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.94
kinase perturbation
0.93
transcription factor
0.93
biological term
0.91
kinase
0.9


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1366.51   (req: < 5)
Gene RIFs: 303   (req: <= 3)
Antibodies: 828   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1366.51   (req: >= 5)
Gene RIFs: 303   (req: > 3)
Antibodies: 828   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 34
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0