Tbio MIS18BP1 Mis18-binding protein 1

Protein Summary

Description

Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.

Uniprot Accession IDs

• Q6P0N0
• D3DSA7
• Q86V14
• Q96PY4
• Q9NUR5
• Q9Y4X9

Gene Name

• MIS18BP1

Ensembl ID

• ENST00000310806
• ENSP00000309790
• ENSG00000129534

Symbol

• C14orf106
• KIAA1903
• KNL2
• M18BP1
• KNL2
• M18BP1
• C14orf106
• HSA242977

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.88
transcription factor perturbation	0.8
histone modification site profile	0.78
gene perturbation	0.7
cell type or tissue	0.69

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.2   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 56   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.2   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 56   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0