Tbio MIS12 Protein MIS12 homolog

Protein Summary

Description

Part of the MIS12 complex which is required for normal chromosome alignment and segregation and for kinetochore formation during mitosis (PubMed:12515822, PubMed:15502821, PubMed:16585270). Essential for proper kinetochore microtubule attachments (PubMed:23891108).

Uniprot Accession IDs

• Q9H081
• Q96N24

Gene Name

• MIS12

Ensembl ID

• ENST00000381165
• ENSP00000370557
• ENSG00000167842
• ENST00000573759
• ENSP00000461252
• ENST00000611091
• ENSP00000484532

Symbol

• MTW1
• hMis12
• KNTC2AP
• 2510025F08Rik

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	1
histone modification site profile	0.74
tissue sample	0.66
microRNA	0.65
transcription factor binding site profile	0.61

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.44   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 149   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.44   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 149   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0