Tdark MIOS GATOR complex protein MIOS

Protein Summary

Description

As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:25457612, PubMed:27487210).

Uniprot Accession IDs

• Q9NXC5
• B2RTV6
• O75216
• Q7L551
• Q9H092

Gene Name

• MIOS

Ensembl ID

• ENST00000340080
• ENSP00000339881
• ENSG00000164654
• ENST00000405785
• ENSP00000384088

Symbol

• MIO
• Sea4
• Yulink

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.93
kinase perturbation	0.84
cell type or tissue	0.75
histone modification site profile	0.72
cell line	0.59

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.02   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 28   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.02   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 28   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (62)

Explore Interacting Targets

1 – 10 of 62

• See Interactions on String-DB

RFPL4B

Tdark

Novelty:  2.42779597

p_int:  0.999997559

p_ni:  0.000002441

Data Source:  BioPlex

SEC13

Tbio

Novelty:  0.00709413

p_int:  0.999996345

p_ni:  0.000003655

Score:  0.999

Data Source:  BioPlex,STRINGDB

CCT2

Tbio

Novelty:  0.01967139

p_int:  0.999979394

p_ni:  0.000020606

Data Source:  BioPlex

CASTOR1

Tbio

Novelty:  0.10145237

p_int:  0.999978292

p_ni:  0.000021698

p_wrong:  1e-8

Score:  0.721

Data Source:  BioPlex,STRINGDB

RGS20

Tbio

Novelty:  0.04087618

p_int:  0.996884574

p_ni:  0.003114873

p_wrong:  5.53e-7

Data Source:  BioPlex

PFDN4

Tbio

Novelty:  0.02133605

p_int:  0.992584564

p_ni:  0.007415436

Data Source:  BioPlex

FAM19A4

Tbio

Novelty:  0.04305684

p_int:  0.991794941

p_ni:  0.008203645

p_wrong:  0.000001414

Data Source:  BioPlex

DOK3

Tbio

Novelty:  0.06212348

p_int:  0.990980059

p_ni:  0.009019941

Score:  0.204

Data Source:  BioPlex,STRINGDB

MFAP5

Tbio

Novelty:  0.01839035

p_int:  0.973528688

p_ni:  0.026363151

p_wrong:  0.000108161

Data Source:  BioPlex

RFPL2

Tdark

Novelty:  1.87914964

p_int:  0.962420077

p_ni:  0.037543918

p_wrong:  0.000036006

Score:  0.181

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (1)

KEGG (1)

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5

1 – 1 of 1

Data Source	Name	Explore in Pharos	Explore in Source
KEGG	mTOR signaling pathway	152 targets	path:hsa04150

Name	Explore in Pharos	Explore in Source
mTOR signaling pathway	152 targets	path:hsa04150

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (9)

Components (6)

Processes (3)

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Items per page:

10

1 – 6 of 6

GO Term	Evidence	Assigned by
cell junction	Inferred from Direct Assay (IDA)	HPA
cytosol	Inferred from Direct Assay (IDA)	HPA
GATOR2 complex	Inferred from Direct Assay (IDA)	SGD
lysosomal membrane	Inferred from Direct Assay (IDA)	UniProtKB
nucleoplasm	Inferred from Direct Assay (IDA)	HPA
nucleus	Inferred from Direct Assay (IDA)	HPA

Disease Associations ()

No disease associations found

GWAS Traits (0)

No GWAS traits found

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UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
Lysosome
Membrane
Phosphoprotein
Reference proteome
Repeat
WD repeat

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	meiosis regulator for oocyte development	VGNC:10499	472289
Macaque	meiosis regulator for oocyte development		696371
Mouse	meiosis regulator for oocyte development	MGI:2182066	252875
Rat	meiosis regulator for oocyte development	RGD:1308432	362324
Dog	meiosis regulator for oocyte development	VGNC:43239	482316

Species	Name	OMA	EggNOG	Inparanoid
Chimp	meiosis regulator for oocyte development
Macaque	meiosis regulator for oocyte development
Mouse	meiosis regulator for oocyte development
Rat	meiosis regulator for oocyte development
Dog	meiosis regulator for oocyte development

Publication Statistics

PubMed Score 22.02

PubMed score by year

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PubTator Score 15.73

PubTator score by year

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Related Publications

Text Mined References (13)

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10

0 of 0

PMID	Year	Title