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Tbio
MINPP1
Multiple inositol polyphosphate phosphatase 1

Protein Summary
Description
Acts as a phosphoinositide 5- and phosphoinositide 6-phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Also acts as a 2,3-bisphosphoglycerate 3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to produce phospho-D-glycerate without formation of 3-phosphoglycerate. May play a role in bone development (endochondral ossification). May play a role in the transition of chondrocytes from proliferation to hypertrophy (By similarity). This gene encodes multiple inositol polyphosphate phosphatase; an enzyme that removes 3-phosphate from inositol phosphate substrates. It is the only enzyme known to hydrolzye inositol pentakisphosphate and inositol hexakisphosphate. This enzyme also converts 2,3 bisphosphoglycerate (2,3-BPG) to 2-phosphoglycerate; an activity formerly thought to be exclusive to 2,3-BPG synthase/2-phosphatase (BPGM) in the Rapoport-Luebering shunt of the glycolytic pathway.[pro ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371994
  • ENSP00000361062
  • ENSG00000107789
  • ENST00000371996
  • ENSP00000361064
  • ENST00000536010
  • ENSP00000437823

Symbol
  • MIPP
  • MIPP
  • HIPER1
  • MINPP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.9
kinase perturbation
0.81
transcription factor binding site profile
0.81
transcription factor
0.75
transcription factor perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.38   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 287   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.38   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 287   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (81)
VWA1
Tbio
Novelty:  0.00212445
p_int:  0.999946194
p_ni:  0.00004866
p_wrong:  0.000005146
Score:  0.165
Data Source:  BioPlex,STRINGDB
C1orf87
Tbio
Novelty:  0.03162594
p_int:  0.999303859
p_ni:  0.000695859
p_wrong:  2.82e-7
Score:  0.169
Data Source:  BioPlex,STRINGDB
HNRNPLL
Tbio
Novelty:  0.0498467
p_int:  0.997730059
p_ni:  0.002269937
p_wrong:  4e-9
Score:  0.174
Data Source:  BioPlex,STRINGDB
MRS2
Tbio
Novelty:  0.00264753
p_int:  0.985880759
p_ni:  0.014119241
Score:  0.161
Data Source:  BioPlex,STRINGDB
SPINK4
Tdark
Family:  Enzyme
Novelty:  0.06706505
p_int:  0.962390089
p_ni:  0.037595626
p_wrong:  0.000014285
Score:  0.188
Data Source:  BioPlex,STRINGDB
LYPD6
Tbio
Novelty:  0.13867181
p_int:  0.947137444
p_ni:  0.05194821
p_wrong:  0.000914346
Score:  0.181
Data Source:  BioPlex,STRINGDB
GDAP1
Tbio
Novelty:  0.00682376
p_int:  0.91018423
p_ni:  0.08981577
Score:  0.622
Data Source:  BioPlex,STRINGDB
GIMAP1
Tbio
Family:  Enzyme
Novelty:  0.16238044
p_int:  0.89604839
p_ni:  0.103946634
p_wrong:  0.000004976
Score:  0.269
Data Source:  BioPlex,STRINGDB
EFNA5
Tbio
Novelty:  0.00134985
p_int:  0.874809037
p_ni:  0.125190691
p_wrong:  2.72e-7
Data Source:  BioPlex
FOXRED1
Tbio
Family:  Enzyme
Novelty:  0.07057772
p_int:  0.848498856
p_ni:  0.151501107
p_wrong:  3.7e-8
Score:  0.173
Data Source:  BioPlex,STRINGDB
Pathways (11)
Inositol phosphate metabolism (R-HSA-1483249)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Inositol phosphate metabolism
Reactome
Metabolism
Reactome
Synthesis of IPs in the ER lumen
Name
Explore in Pharos
Explore in Source
Inositol phosphate metabolism
Metabolism
Synthesis of IPs in the ER lumen
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
1
1
61.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
61.1
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
multiple inositol-polyphosphate phosphatase 1
VGNC:5522
450579
Macaque
multiple inositol-polyphosphate phosphatase 1
704362
Mouse
MGI:1336159
17330
Rat
RGD:1564801
499084
Dog
multiple inositol-polyphosphate phosphatase 1
486462
Species
Name
OMA
EggNOG
Inparanoid
Chimp
multiple inositol-polyphosphate phosphatase 1
Macaque
multiple inositol-polyphosphate phosphatase 1
Mouse
Rat
Dog
multiple inositol-polyphosphate phosphatase 1
Publication Statistics
PubMed Score 50.38
PubMed score by year
PubTator Score 24.92
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title