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Tbio
MINDY1
Ubiquitin carboxyl-terminal hydrolase MINDY-1

Protein Summary
Description
Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312210
  • ENSP00000310923
  • ENSG00000143409
  • ENST00000361738
  • ENSP00000354669
  • ENST00000361936
  • ENSP00000354814
  • ENST00000493834
  • ENSP00000437174
  • ENST00000622754
  • ENSP00000481304

Symbol
  • FAM63A
  • KIAA1390
  • FAM63A
  • MINDY-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.36   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 81   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.36   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 81   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (60)
RNF126
Tbio
Family:  Enzyme
Novelty:  0.08123801
p_int:  0.999955593
p_ni:  0.000044407
Score:  0.227
Data Source:  BioPlex,STRINGDB
CHIA
Tchem
Family:  Enzyme
Novelty:  0.00181726
p_int:  0.997908613
p_ni:  0.002091355
p_wrong:  3.2e-8
Score:  0.217
Data Source:  BioPlex,STRINGDB
MANSC1
Tdark
Novelty:  0.91681036
p_int:  0.997406238
p_ni:  0.002593703
p_wrong:  5.9e-8
Data Source:  BioPlex
KDELR1
Tbio
Novelty:  0.0036468
p_int:  0.994367783
p_ni:  0.002025076
p_wrong:  0.003607141
Score:  0.182
Data Source:  BioPlex,STRINGDB
OR2G6
Tdark
Family:  oGPCR
p_int:  0.993357908
p_ni:  0.005518061
p_wrong:  0.001124031
Data Source:  BioPlex
GRTP1
Tdark
Novelty:  0.8841166
p_int:  0.993127838
p_ni:  0.006245827
p_wrong:  0.000626335
Score:  0.227
Data Source:  BioPlex,STRINGDB
SEL1L3
Tdark
Novelty:  0.62775736
p_int:  0.993089654
p_ni:  0.002775361
p_wrong:  0.004134985
Score:  0.19
Data Source:  BioPlex,STRINGDB
KCNA10
Tclin
Family:  IC
Novelty:  0.05708808
p_int:  0.992464842
p_ni:  0.007263551
p_wrong:  0.000271607
Score:  0.167
Data Source:  BioPlex,STRINGDB
TMEM63C
Tdark
Family:  IC
Novelty:  0.02849254
p_int:  0.986497066
p_ni:  0.013218004
p_wrong:  0.00028493
Data Source:  BioPlex
TMEM31
Tdark
Novelty:  0.65381391
p_int:  0.979022979
p_ni:  0.020903846
p_wrong:  0.000073175
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (36)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
7
4
7
9.2
96.2
apolipoprotein A 1 measurement
2
3
3
95.6
sex hormone-binding globulin measurement
6
2
6
89.7
creatinine measurement
4
4
5
88.9
high density lipoprotein cholesterol measurement
3
2
3
85
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
7
9.2
96.2
apolipoprotein A 1 measurement
3
95.6
sex hormone-binding globulin measurement
6
89.7
creatinine measurement
5
88.9
high density lipoprotein cholesterol measurement
3
85
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
MINDY lysine 48 deubiquitinase 1
VGNC:6810
469483
Macaque
MINDY lysine 48 deubiquitinase 1
716225
Mouse
MGI:1922257
75007
Rat
RGD:1559660
310665
Dog
MINDY lysine 48 deubiquitinase 1
VGNC:43236
483188
Species
Name
OMA
EggNOG
Inparanoid
Chimp
MINDY lysine 48 deubiquitinase 1
Macaque
MINDY lysine 48 deubiquitinase 1
Mouse
Rat
Dog
MINDY lysine 48 deubiquitinase 1
Publication Statistics
PubMed Score 5.36
PubMed score by year
PubTator Score 2.33
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title