Tbio MILR1 Allergin-1

Protein Summary

Description

Immunoglobulin-like receptor which plays an inhibitory role in degranulation of mast cells. Negatively regulates IgE-mediated mast cell activation and suppresses the type I immediate hypersensitivity reaction (By similarity).

Uniprot Accession IDs

• Q7Z6M3
• A1L458
• B4DUS1
• B7ZM50
• B9EGN0
• D6RUW6
• D6RUW8

Gene Name

• MILR1

Ensembl ID

• ENST00000612535
• ENSP00000477504
• ENSG00000271605
• ENST00000615220
• ENSP00000480749
• ENST00000616498
• ENSP00000481318
• ENST00000619286
• ENSP00000482801

Symbol

• C17orf60
• MCA32
• MCA32
• MCA-32
• C17orf60
• Allergin-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.85
tissue	0.83
cellular component	0.62
tissue sample	0.59
chemical	0.41

Protein Classes

PANTHER Classes

Protein / Cell Adhesion Molecule / Allergin-1

DTO Classes

Protein / Cell Adhesion / Allergin-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.73   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 95   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.73   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 95   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (12)

Explore Interacting Targets

1 – 10 of 12

• See Interactions on String-DB

RYK

Tbio

Family:  Kinase

Novelty:  0.00910227

p_int:  0.999200401

p_ni:  0.000174654

p_wrong:  0.000624945

Score:  0.188

Data Source:  BioPlex,STRINGDB

PLAA

Tchem

Family:  Enzyme

Novelty:  0.01164687

p_int:  0.980192643

p_ni:  0.019807357

Score:  0.23

Data Source:  BioPlex,STRINGDB

INPPL1

Tchem

Family:  Enzyme

Novelty:  0.00634126

p_int:  0.96909872

p_ni:  0.03090128

Score:  0.184

Data Source:  BioPlex,STRINGDB

GBF1

Tbio

Novelty:  0.10901631

p_int:  0.912125224

p_ni:  0.087874776

Score:  0.188

Data Source:  BioPlex,STRINGDB

PTPRD

Tbio

Family:  Enzyme

Novelty:  0.01059407

p_int:  0.890595433

p_ni:  0.10902636

p_wrong:  0.000378208

Data Source:  BioPlex

FHL2

Tbio

Novelty:  0.00501273

p_int:  0.827765455

p_ni:  0.145519053

p_wrong:  0.026715492

Score:  0.181

Data Source:  BioPlex,STRINGDB

GLMN

Tbio

Novelty:  0.01940401

p_int:  0.791295924

p_ni:  0.208704073

p_wrong:  4e-9

Data Source:  BioPlex

IGSF1

Tbio

Novelty:  0.02173741

Score:  0.546

Data Source:  STRINGDB

CD300A

Tbio

Novelty:  0.01745189

Score:  0.542

Data Source:  STRINGDB

CD302

Tbio

Novelty:  0.01156975

Score:  0.51

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (4)

Components (2)

Processes (2)

Find Similar Targets

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
integral component of plasma membrane	Non-traceable Author Statement (NAS)	UniProtKB
mast cell granule	Inferred from Electronic Annotation (IEA)	GOC

Disease Associations (null)

No disease associations found

GWAS Traits (5)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 5

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	2	1	2		68.6
sex hormone-binding globulin measurement	EFO_0004696	2	2	2		49.2
cardiac troponin I measurement	EFO_0010071	1	1	1		48.5
vital capacity	EFO_0004312	1	1	1		31.4
asthma	EFO_0000270	1	1	0	1	24.5

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 5

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	2		68.6
sex hormone-binding globulin measurement	EFO_0004696	2		49.2
cardiac troponin I measurement	EFO_0010071	1		48.5
vital capacity	EFO_0004312	1		31.4
asthma	EFO_0000270	0	1	24.5

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Cell membrane
Complete proteome
Disulfide bond
Glycoprotein
Immunoglobulin domain
Membrane
Phosphoprotein
Reference proteome
Repeat

GWAS Trait Find Similar Targets

No Header	No Header
asthma
cardiac troponin I measurement
heel bone mineral density
sex hormone-binding globulin measurement
vital capacity

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
hematopoietic system phenotype
immune system phenotype

IDG Resources

No IDG generated resources found

Orthologs (2)

1 – 2 of 2

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Dog	mast cell immunoglobulin like receptor 1	VGNC:43235	480473
Cow	mast cell immunoglobulin like receptor 1	VGNC:31476	789682

Species	Name	OMA	EggNOG	Inparanoid
Dog	mast cell immunoglobulin like receptor 1
Cow	mast cell immunoglobulin like receptor 1

Publication Statistics

PubMed Score 16.73

PubMed score by year

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PubTator Score 4.43

PubTator score by year

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Related Publications

Text Mined References (5)

GeneRif Annotations (3)

Items per page:

10

0 of 0

PMID	Year	Title