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Tbio
MILR1
Allergin-1

Protein Summary
Description
Immunoglobulin-like receptor which plays an inhibitory role in degranulation of mast cells. Negatively regulates IgE-mediated mast cell activation and suppresses the type I immediate hypersensitivity reaction (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000612535
  • ENSP00000477504
  • ENSG00000271605
  • ENST00000615220
  • ENSP00000480749
  • ENST00000616498
  • ENSP00000481318
  • ENST00000619286
  • ENSP00000482801

Symbol
  • C17orf60
  • MCA32
  • MCA32
  • MCA-32
  • C17orf60
  • Allergin-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.85
tissue
0.83
cellular component
0.62
tissue sample
0.59
chemical
0.41


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.73   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 95   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.73   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 95   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (12)
RYK
Tbio
Family:  Kinase
Novelty:  0.00910227
p_int:  0.999200401
p_ni:  0.000174654
p_wrong:  0.000624945
Score:  0.188
Data Source:  BioPlex,STRINGDB
PLAA
Tchem
Family:  Enzyme
Novelty:  0.01164687
p_int:  0.980192643
p_ni:  0.019807357
Score:  0.23
Data Source:  BioPlex,STRINGDB
INPPL1
Tchem
Family:  Enzyme
Novelty:  0.00634126
p_int:  0.96909872
p_ni:  0.03090128
Score:  0.184
Data Source:  BioPlex,STRINGDB
GBF1
Tbio
Novelty:  0.10901631
p_int:  0.912125224
p_ni:  0.087874776
Score:  0.188
Data Source:  BioPlex,STRINGDB
PTPRD
Tbio
Family:  Enzyme
Novelty:  0.01059407
p_int:  0.890595433
p_ni:  0.10902636
p_wrong:  0.000378208
Data Source:  BioPlex
FHL2
Tbio
Novelty:  0.00501273
p_int:  0.827765455
p_ni:  0.145519053
p_wrong:  0.026715492
Score:  0.181
Data Source:  BioPlex,STRINGDB
GLMN
Tbio
Novelty:  0.01940401
p_int:  0.791295924
p_ni:  0.208704073
p_wrong:  4e-9
Data Source:  BioPlex
IGSF1
Tbio
Novelty:  0.02173741
Score:  0.546
Data Source:  STRINGDB
CD300A
Tbio
Novelty:  0.01745189
Score:  0.542
Data Source:  STRINGDB
CD302
Tbio
Novelty:  0.01156975
Score:  0.51
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
1
2
68.6
sex hormone-binding globulin measurement
2
2
2
49.2
cardiac troponin I measurement
1
1
1
48.5
vital capacity
1
1
1
31.4
1
1
0
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
68.6
sex hormone-binding globulin measurement
2
49.2
cardiac troponin I measurement
1
48.5
vital capacity
1
31.4
0
1
24.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Dog
mast cell immunoglobulin like receptor 1
VGNC:43235
480473
Cow
mast cell immunoglobulin like receptor 1
VGNC:31476
789682
Species
Name
OMA
EggNOG
Inparanoid
Dog
mast cell immunoglobulin like receptor 1
Cow
mast cell immunoglobulin like receptor 1
Publication Statistics
PubMed Score 16.73
PubMed score by year
PubTator Score 4.43
PubTator score by year
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Related Publications
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PMID
Year
Title