Tbio MILR1 Allergin-1

Protein Summary

Description

Immunoglobulin-like receptor which plays an inhibitory role in degranulation of mast cells. Negatively regulates IgE-mediated mast cell activation and suppresses the type I immediate hypersensitivity reaction (By similarity).

Uniprot Accession IDs

• Q7Z6M3
• A1L458
• B4DUS1
• B7ZM50
• B9EGN0
• D6RUW6
• D6RUW8

Gene Name

• MILR1

Ensembl ID

• ENST00000612535
• ENSP00000477504
• ENSG00000271605
• ENST00000615220
• ENSP00000480749
• ENST00000616498
• ENSP00000481318
• ENST00000619286
• ENSP00000482801

Symbol

• C17orf60
• MCA32
• MCA32
• MCA-32
• C17orf60
• Allergin-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.85
tissue	0.83
cellular component	0.62
tissue sample	0.59
chemical	0.41

Protein Classes

PANTHER Classes

Protein / Cell Adhesion Molecule / Allergin-1

DTO Classes

Protein / Cell Adhesion / Allergin-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.64   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 95   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.64   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 95   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0